Document Detail


Prediction of outcome at school age in neonatal intensive care unit graduates using neonatal neurologic tools.
MedLine Citation:
PMID:  11063077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prediction of outcome for neonatal intensive care unit graduates is clinically useful to counsel families effectively and target those who may benefit from early interventions. Evoked potentials have proven prognostic value of neurologic outcomes in early childhood; however, their long-term predictive validity remains to be determined. The objective of this prospective study was to determine the long-term predictive value of three neonatal neurologic assessments: brainstem auditory evoked potentials, somatosensory evoked potentials, and the Einstein Neonatal Neurobehavioral Assessment Scale. Seventy-eight high-risk newborns and 28 healthy controls were recruited and were assessed in the newborn period using these tests. At 8 to 9 years of age, 42 subjects and 13 controls were re-evaluated for developmental progress using a range of psychologic, sensorimotor, and neurologic measures. Findings indicated that the somatosensory evoked potential was most accurate at predicting outcome at school age, with high specificity (83-100%) across all domains tested and good sensitivity (80-100%) for intellectual performance and sensorimotor abilities. The brainstem auditory evoked potential was limited by false-negatives, whereas the neonatal neurobehavioral assessment yielded many false-positives. This study provides new evidence that associations between neonatal somatosensory evoked potentials and developmental sequelae continue to be significant at school age.
Authors:
A Majnemer; B Rosenblatt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of child neurology     Volume:  15     ISSN:  0883-0738     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  645-51     Citation Subset:  IM    
Affiliation:
School of Physical and Occupational Therapy, Department of Neurology, McGill University-Montreal Children's Hospital, PQ, Canada. amajne@po-box.mcgill.ca
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MeSH Terms
Descriptor/Qualifier:
Brain Diseases / rehabilitation,  therapy*
Child
Child, Preschool
Evoked Potentials, Auditory, Brain Stem
Evoked Potentials, Somatosensory
Follow-Up Studies
Hospitalization
Humans
Infant
Infant, Newborn
Intensive Care Units, Neonatal*
Predictive Value of Tests
Prospective Studies
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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