Document Detail

Prediction of an occupational exposure limit for a mixture on the basis of its components: application to metalworking fluids.
MedLine Citation:
PMID:  8776194     Owner:  NLM     Status:  MEDLINE    
Using a previously developed mouse bioassay, a semisynthetic metalworking fluid (MWF "B") and its major components were evaluated. In mice MWF "B" and its components produced both sensory (S) and pulmonary (P) irritation. Using respiratory frequency (f) depression, concentration-response relationships were developed for each component as well as for MWF "B." From such relationships the concentration capable of evoking a 50% decrease in mean f was determined for each component and designated as RD50S if the decrease in f was due to sensory irritation, or RD50P if the decrease in f was due to pulmonary irritation. Based on RD50P values, the results indicated that the alkanolamides, potassium soap, sodium sulfonate, and triazine components were similar in irritation potency both to one another and to MWF "B." Through an examination of potency and fractional composition it was concluded that these five components largely contributed to the irritancy of MWF "B." From the RD50P values, occupational exposure limits that would protect workers from respiratory irritation were proposed for MWF "B" and each of its components. Using the approach of the American Conference of Governmental Industrial Hygienists for mixtures, an occupational exposure limit was calculated for MWF "B" employing the component data. The two limits for MWF "B" were similar to one another, suggesting that exposure limits for MWFs may be obtained through the evaluation of the fluids themselves or through evaluation of the components.
S P Krystofiak; M M Schaper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  American Industrial Hygiene Association journal     Volume:  57     ISSN:  0002-8894     ISO Abbreviation:  Am Ind Hyg Assoc J     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-12-03     Completed Date:  1996-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0371160     Medline TA:  Am Ind Hyg Assoc J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  239-44     Citation Subset:  IM; S    
Center for Environmental and Occupational Health and Toxicology, University of Pittsburgh, PA 15238, USA.
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MeSH Terms
Atmosphere Exposure Chambers
Maximum Allowable Concentration
Mice, Inbred Strains
Occupational Exposure*

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