Document Detail

Prediction of neurodevelopmental outcome in the preterm infant: MR-staged myelination compared with cranial US.
MedLine Citation:
PMID:  2179986     Owner:  NLM     Status:  MEDLINE    
In this prospective study, 26 very preterm infants underwent magnetic resonance (MR) imaging of the brain at 44 weeks postmenstrual age (PMA) for staging of myelination. Neurodevelopmental outcome was assessed at 1 year of age. A significant correlation was demonstrated between delayed myelination and neurodevelopmental outcome (Chi 2 = 16.6, P = .01). A significant correlation was also found between ultrasound (US) findings in the neonatal period and outcome at 1 year (Chi 2 = 22.9, P = .03). To establish the criterion with the best predictive value, a multiple regression analysis was performed with periventricular-intraventricular hemorrhage, periventricular leukomalacia (PVL), and the stage of myelination at 44 weeks PMA as independent variables and neurodevelopmental outcome at 1 year of age as a dependent variable. Staging of myelination with MR imaging in the early postnatal period of very preterm infants had predictive value with regard to neurodevelopmental outcome. Detection of PVL with US, however, showed a better correlation with outcome, a result that seems to limit the potential role of MR imaging in this population for this purpose only.
G L Guit; M van de Bor; L den Ouden; J H Wondergem
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Radiology     Volume:  175     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-04-25     Completed Date:  1990-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  107-9     Citation Subset:  AIM; IM    
Department of Diagnostic Radiology, University Hospital Leiden, The Netherlands.
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MeSH Terms
Cerebral Hemorrhage / diagnosis*,  physiopathology
Encephalomalacia / diagnosis*
Infant, Newborn
Infant, Premature, Diseases / diagnosis*,  physiopathology
Leukomalacia, Periventricular / diagnosis*,  physiopathology
Magnetic Resonance Imaging*
Myelin Sheath / physiology*
Nervous System / growth & development*
Comment In:
Radiology. 1990 Dec;177(3):885-6   [PMID:  2078226 ]

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