Document Detail

Prediction of neurodevelopmental outcome after hypoxic-ischemic encephalopathy treated with hypothermia by diffusion tensor imaging analyzed using tract-based spatial statistics.
MedLine Citation:
PMID:  22447318     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Objective biomarkers are needed to assess neuroprotective therapies after perinatal hypoxic-ischemic encephalopathy (HIE). We tested the hypothesis that, in infants who underwent therapeutic hypothermia after perinatal HIE, neurodevelopmental performance was predicted by fractional anisotropy (FA) values in the white matter (WM) on early diffusion tensor imaging (DTI) as assessed by means of tract-based spatial statistics (TBSS).
METHODS: We studied 43 term infants with HIE. Developmental assessments were carried out at a median (range) age of 24 (12-28) mo.
RESULTS: As compared with infants with favorable outcomes, those with unfavorable outcomes had significantly lower FA values (P < 0.05) in the centrum semiovale, corpus callosum (CC), anterior and posterior limbs of the internal capsule, external capsules, fornix, cingulum, cerebral peduncles, optic radiations, and inferior longitudinal fasciculus. In a second analysis in 32 assessable infants, the Griffiths Mental Development Scales (Revised) (GMDS-R) showed a significant linear correlation (P < 0.05) between FA values and developmental quotient (DQ) and all its component subscale scores.
DISCUSSION: DTI analyzed by TBSS provides a qualified biomarker that can be used to assess the efficacy of additional neuroprotective therapies after HIE.
Nora Tusor; Courtney Wusthoff; Natalie Smee; Nazakat Merchant; Tomoki Arichi; Joanna M Allsop; Frances M Cowan; Denis Azzopardi; A David Edwards; Serena J Counsell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-23
Journal Detail:
Title:  Pediatric research     Volume:  72     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-19     Completed Date:  2012-10-15     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  63-9     Citation Subset:  IM    
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MeSH Terms
Biological Markers
Brain / growth & development*
Child Development / physiology*
Diffusion Tensor Imaging
Hypothermia, Induced / adverse effects*,  methods
Hypoxia-Ischemia, Brain / physiopathology*,  therapy*
Intelligence Tests
Neuroanatomical Tract-Tracing Techniques
Grant Support
MC_U120081323//Medical Research Council; //Medical Research Council
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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