Document Detail

Prediction of morbidity during infancy after repair of congenital diaphragmatic hernia.
MedLine Citation:
PMID:  8986979     Owner:  NLM     Status:  MEDLINE    
Recent studies have suggested there may be a high incidence of pulmonary and extrapulmonary sequelae among infants who have undergone repair of congenital diaphragmatic hernia (CDH). The aim of this study was to identify factors that predict high-risk cases to facilitate counseling of parents. Morbidity, defined as conditions requiring treatment and/or hospitalization during follow-up, was documented. Only five of 15 cases that had been diagnosed antenatally (at 16 to 26 weeks' gestation) and underwent surgical repair after preoperative stabilization were without morbidity at the time of follow-up. Respiratory problems were identified in seven (chylothorax in 3, recurrent infections in 4) and failure to thrive in four; three infants required further gastrointestinal surgery. A comparison of infants with and without morbidity showed that the only significant difference between the groups was in the duration of respiratory support. A requirement for respiratory support for more than 10 days had 90% sensitivity, 100% specificity, and a positive predictive value for morbidity at follow-up of 100%.
S Naik; A Greenough; Y X Zhang; M Davenport
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  31     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-04-09     Completed Date:  1997-04-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1651-4     Citation Subset:  IM    
Department of Child Health, King's College Hospital, London, England.
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MeSH Terms
Follow-Up Studies
Hernia, Diaphragmatic / congenital,  epidemiology,  surgery*
Infant, Newborn
Postoperative Complications / epidemiology*,  etiology
Prenatal Diagnosis
Respiratory Therapy* / adverse effects
Respiratory Tract Diseases / epidemiology,  etiology
Sensitivity and Specificity
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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