| Prediction models for the risk of cardiovascular disease in patients with type 2 diabetes: a systematic review. | |
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MedLine Citation:
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PMID: 22184101 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ContextA recent overview of all CVD models applicable to diabetes patients is not available.ObjectiveTo review the primary prevention studies that focused on the development, validation and impact assessment of a cardiovascular risk model, scores or rules that can be applied to patients with type 2 diabetes.DesignSystematic review.Data sourcesMedline was searched from 1966 to 1 April 2011.Study selectionA study was eligible when it described the development, validation or impact assessment of a model that was constructed to predict the occurrence of cardiovascular disease in people with type 2 diabetes, or when the model was designed for use in the general population but included diabetes as a predictor.Data extractionA standardized form was sued to extract all data of the CVD models.Results45 prediction models were identified, of which 12 were specifically developed for patients with type 2 diabetes. Only 31% of the risk scores has been externally validated in a diabetes population, with an area under the curve ranging from 0.61 to 0.86 and 0.59 to 0.80 for models developed in a diabetes population and in the general population, respectively. Only one risk score has been studied for its effect on patient management and outcomes. 10% of the risk scores are advocated in national diabetes guidelines.ConclusionMany cardiovascular risk scores are available that can be applied to patients with type 2 diabetes. A minority of these risk scores has been validated and tested for its predictive accuracy, with only a few showing a discriminative value of ≥0.80. The impact of applying these risk scores in clinical practice is almost completely unknown, but their use is recommended in various national guidelines. |
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Authors:
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S van Dieren; J W J Beulens; A P Kengne; L M Peelen; G E H M Rutten; M Woodward; Y T van der Schouw; K G M Moons |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-18 |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: - ISSN: 1468-201X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University Medical Center Utrecht, Utrecht, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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