Document Detail

Prediction of maternal complications and adverse infant outcome at admission for temporizing management of early-onset severe hypertensive disorders of pregnancy.
MedLine Citation:
PMID:  16643825     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We explored the association between clinical parameters at admission and the subsequent development of major maternal complications or adverse infant outcome in women with hypertensive complications of pregnancy remote from term. STUDY DESIGN: We drew data from a randomized trial of temporizing management in 216 patients with hemolysis, elevated liver enzymes, and low platelets syndrome; severe preeclampsia; eclampsia; or hypertension-related fetal growth restriction and gestational ages between 24 and 34 completed weeks. End points were adverse infant outcome (perinatal death, severe morbidity) and major maternal complications (major morbidity; recurrent and newly acquired hemolysis, elevated liver enzymes, and low platelets; eclampsia) after admission. End point prevalences were comparable between the treatment and control groups. The association with age, parity, ethnicity, body mass index, gestational age, estimated fetal weight, blood pressure, antihypertensive medication, pulse rate, hemoglobin concentration, admitting center, diagnosis at inclusion, chronic hypertension, and thrombophilia was explored by logistic regression analysis. RESULTS: Adverse infant outcome was predominantly influenced by gestational age (odds ratio 0.4 per week increment). Major maternal complications were correlated to multiparity (odds ratio 0.4) and estimated fetal weight (odds ratio 0.9 per 100-g increment). CONCLUSION: Prediction at admission of the clinical course of the disease and the development of additional maternal complications was not feasible.
Wessel Ganzevoort; Annelies Rep; Johanna I P de Vries; Gouke J Bonsel; Hans Wolf;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-04-27
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  195     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-07     Completed Date:  2006-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  495-503     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Academic Medical Centre, Amsterdam, The Netherlands.
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MeSH Terms
Birth Weight
Eclampsia / therapy
Gestational Age
HELLP Syndrome / therapy
Hypertension, Pregnancy-Induced / therapy*
Infant, Newborn
Maternal Age
Multivariate Analysis
Pre-Eclampsia / therapy
Pregnancy Outcome / epidemiology*
ROC Curve
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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