Document Detail

Prediction of major arrhythmic events and sudden cardiac death in dilated cardiomyopathy. The Marburg Cardiomyopathy Study design and description of baseline clinical characteristics.
MedLine Citation:
PMID:  10904838     Owner:  NLM     Status:  MEDLINE    
The Marburg Cardiomyopathy Study (MACAS) is a prospective observational study designed to determine the value of the following potential non-invasive arrhythmia risk predictors in more than 200 patients with idiopathic dilated cardiomyopathy (IDC) over a 5-year follow-up period: New York Heart Association functional class, left ventricular end-diastolic diameter and ejection fraction, left bundle branch block and atrial fibrillation on ECG, QTc and JTc-dispersion on 12-lead ECG, abnormal time-domain analysis and spectral turbulence analysis of the signal-averaged ECG, ventricular arrhythmias and heart-rate variability on 24-hour Holter ECG, baroreflex sensitivity, and microvolt T wave alternans during exercise. This report describes the rationale of MACAS as well as the clinical characteristics of the first 236 patients enrolled between March 1996 and October 1999. The prognostic significance of the potential arrhythmia risk predictors in MACAS will be determined by multivariate Cox analysis at the end of 5-year follow-up. Primary endpoints are total mortality and major arrhythmic events defined as sustained ventricular tachycardia, ventricular fibrillation or sudden cardiac death. The results of MACAS will have important implications for the design of future studies evaluating the role of prophylactic defibrillator therapy in idiopathic dilated cardiomyopathy.
W Grimm; J Hoffmann; V Menz; H H Müller; B Maisch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Herz     Volume:  25     ISSN:  0340-9937     ISO Abbreviation:  Herz     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-10-02     Completed Date:  2000-10-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7801231     Medline TA:  Herz     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  189-99     Citation Subset:  IM    
Department of Internal Medicine-Cardiology, Philipps University, Marburg, Germany.
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MeSH Terms
Atrial Fibrillation / diagnosis*,  physiopathology
Bundle-Branch Block / diagnosis*,  physiopathology
Cardiomyopathy, Dilated / diagnosis*,  physiopathology
Death, Sudden, Cardiac / etiology*,  prevention & control
Electrocardiography, Ambulatory
Follow-Up Studies
Heart Failure / diagnosis,  physiopathology
Hemodynamics / physiology
Middle Aged
Pressoreceptors / physiopathology
Prospective Studies
Risk Factors
Signal Processing, Computer-Assisted
Ventricular Fibrillation / diagnosis*,  physiopathology

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