Document Detail

Prediction of locally recurrent prostate cancer after radiation therapy: incremental value of 3T diffusion-weighted MRI.
MedLine Citation:
PMID:  19161194     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To prospectively evaluate the incremental value of diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) maps in addition to T2-weighted imaging (T2WI) for predicting locally recurrent prostate cancer in patients with biochemical failure after radiation therapy. MATERIALS AND METHODS: Thirty-six consecutive patients with an increased prostate-specific antigen level after radiation therapy underwent 3T MRI followed by transrectal biopsy. The MRI findings and biopsy results were correlated in sextant prostate sectors of peripheral zones (PZs). Two radiologists in consensus reviewed T2WI and combined T2WI and DWI with ADC maps, and rated the likelihood of recurrent cancer on a five-point scale. ADC values were calculated for recurrent cancer and benign tissue. RESULTS: Of 216 sectors, 65 prostate sectors (30%) were positive for cancer in 18 patients. For predicting recurrent cancer, combined T2WI and DWI showed a greater sensitivity compared to T2WI (P < 0.001). A significantly greater area under the receiver operating characteristics curve (Az) was determined for combined T2WI and DWI (Az = 0.879, P < 0.01) as compared to T2WI (Az = 0.612). Mean ADC values between recurrent cancer and benign tissue showed a statistically significant difference (P < 0.01). CONCLUSION: For predicting locally recurrent prostate cancer after radiation therapy, the use of combined T2WI and DWI showed a better diagnostic performance compared to T2WI.
Chan Kyo Kim; Byung Kwan Park; Hyun Moo Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  29     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-28     Completed Date:  2009-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  391-7     Citation Subset:  IM    
Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
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MeSH Terms
Aged, 80 and over
Chi-Square Distribution
Diffusion Magnetic Resonance Imaging / methods*
Image Processing, Computer-Assisted
Middle Aged
Neoplasm Recurrence, Local / pathology*
Predictive Value of Tests
Prospective Studies
Prostatic Neoplasms / pathology*,  radiotherapy
ROC Curve
Sensitivity and Specificity

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