| Prediction of locally recurrent prostate cancer after radiation therapy: incremental value of 3T diffusion-weighted MRI. | |
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MedLine Citation:
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PMID: 19161194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To prospectively evaluate the incremental value of diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) maps in addition to T2-weighted imaging (T2WI) for predicting locally recurrent prostate cancer in patients with biochemical failure after radiation therapy. MATERIALS AND METHODS: Thirty-six consecutive patients with an increased prostate-specific antigen level after radiation therapy underwent 3T MRI followed by transrectal biopsy. The MRI findings and biopsy results were correlated in sextant prostate sectors of peripheral zones (PZs). Two radiologists in consensus reviewed T2WI and combined T2WI and DWI with ADC maps, and rated the likelihood of recurrent cancer on a five-point scale. ADC values were calculated for recurrent cancer and benign tissue. RESULTS: Of 216 sectors, 65 prostate sectors (30%) were positive for cancer in 18 patients. For predicting recurrent cancer, combined T2WI and DWI showed a greater sensitivity compared to T2WI (P < 0.001). A significantly greater area under the receiver operating characteristics curve (Az) was determined for combined T2WI and DWI (Az = 0.879, P < 0.01) as compared to T2WI (Az = 0.612). Mean ADC values between recurrent cancer and benign tissue showed a statistically significant difference (P < 0.01). CONCLUSION: For predicting locally recurrent prostate cancer after radiation therapy, the use of combined T2WI and DWI showed a better diagnostic performance compared to T2WI. |
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Authors:
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Chan Kyo Kim; Byung Kwan Park; Hyun Moo Lee |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 29 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-28 Completed Date: 2009-03-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 391-7 Citation Subset: IM |
Affiliation:
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Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. chankyokim@skku.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Biopsy Chi-Square Distribution Diffusion Magnetic Resonance Imaging / methods* Humans Image Processing, Computer-Assisted Male Middle Aged Neoplasm Recurrence, Local / pathology* Predictive Value of Tests Prospective Studies Prostatic Neoplasms / pathology*, radiotherapy ROC Curve Sensitivity and Specificity |
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