| Prediction of incident diabetes mellitus by baseline IGF1 levels. | |
| | |
MedLine Citation:
|
PMID: 21059863 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVE: IGF1 is associated with metabolic parameters and involved in glucose metabolism. Low-IGF1 has been implicated in the etiology of glucose intolerance and subjects with pathological causes of either low- or high-IGF1 are at risk of diabetes. We hypothesized that both low- and high-IGF1 levels increase the risk of diabetes and aimed to assess the role of IGF1 in the risk of developing diabetes in a large prospective study. DESIGN: An analysis of two prospective cohort studies, the DETECT study and SHIP. METHODS: We measured IGF1 levels in 7777 nondiabetic subjects and assessed incident diabetes mellitus during follow-up. RESULTS: There were 464 cases of incident diabetes during 32 229 person-years (time of follow-up in the DETECT study and SHIP: 4.5 and 5 years respectively). There was no heterogeneity between both studies (P > 0.4). The hazard ratios (HRs) of incident diabetes in subjects with IGF1 levels below the 10th or above the 90th age- and sex-specific percentile, compared to subjects with intermediate IGF1 levels, were 1.44 (95% confidence interval (CI) 1.07-1.94) and 1.55 (95% CI 1.06-2.06) respectively, after multiple adjustment. After further adjustment for metabolic parameters, the HR for low-IGF1 became insignificant. Analysis of IGF1 quintiles revealed a U-shaped association of IGF1 with risk of diabetes. Results remained similar after exclusion of patients with onset of new diabetes within 1 year or with borderline glucose or HbA1c levels at baseline. CONCLUSIONS: Subjects with low- or high-IGF1 level are at increased risk of developing diabetes. |
| | |
Authors:
|
Harald Jörn Schneider; Nele Friedrich; Jens Klotsche; Sabine Schipf; Matthias Nauck; Henry Völzke; Caroline Sievers; Lars Pieper; Winfried März; Hans-Ulrich Wittchen; Günter Karl Stalla; Henri Wallaschofski |
Related Documents
:
|
9295313 - Glucose increases both the plasma membrane number and phosphorylation of insulin-like g... 15662223 - Vascular responses to igf-i and insulin are impaired in aortae of hypertensive rats. 16939333 - Salt-induced changes in pork myofibrillar tissue investigated by ft-ir microspectroscop... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-08 |
Journal Detail:
|
Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 164 ISSN: 1479-683X ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
|
Languages: eng Pagination: 223-9 Citation Subset: IM |
Affiliation:
|
Medizinische Klinik-Innenstadt, Ludwig-Maximilians University, Munich, Germany. harald.schneider@med.uni-muenchen.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serum proteome changes in acromegalic patients following transsphenoidal surgery: novel biomarkers o...
Next Document: The prevalence of thyroid disorders during early pregnancy in China: the benefits of universal scree...