| Prediction of in vivo short-chain fatty acid production in hindgut fermenting mammals: problems and pitfalls. | |
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MedLine Citation:
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PMID: 20694924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Short-chain fatty acids (SCFA) are considered to have important physiological functions. However, to prove this, SCFA must be determined, which is rather difficult as a lot of factors interfere with their production. This review focuses on the factors that influence the prediction of short-chain fatty acid formation in the large intestine of monogastric mammals. To mimic the in vivo situation, when predicting the amount of short-chain fatty acids produced from a certain substrate based on in vitro models, one has to estimate the amount of this substrate entering the large intestine, the retention time in the different parts of the large intestine, and the substrate fermentability. Instead of in vitro models, direct and indirect techniques may be used to measure short-chain fatty acid production in vivo. Direct techniques include the measurement of input and output or measuring differences in SCFA between portal and venous blood whereas indirect techniques measure the end products of fermentation. In this case, other factors have to be taken into account, including technical limitations and ethical considerations. In this review it is concluded that the choice for a method will rely on the purpose of the study taking into account the (dis)advantages of every method. |
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Authors:
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S Millet; M J Van Oeckel; M Aluwé; E Delezie; D L De Brabander |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Critical reviews in food science and nutrition Volume: 50 ISSN: 1549-7852 ISO Abbreviation: Crit Rev Food Sci Nutr Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-09 Completed Date: 2010-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8914818 Medline TA: Crit Rev Food Sci Nutr Country: England |
Other Details:
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Languages: eng Pagination: 605-19 Citation Subset: IM |
Affiliation:
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Animal Sciences Unit, Institute for Agricultural and Fisheries Research (ILVO), Melle, Belgium. sam.millet@ilvo.vlaanderen.be |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fatty Acids, Volatile / metabolism* Fermentation / physiology* Intestine, Large / metabolism*, microbiology* Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Volatile |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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