Document Detail

Prediction of impending blast cell transformation in chronic granulocytic leukaemia.
MedLine Citation:
PMID:  3166449     Owner:  NLM     Status:  MEDLINE    
Bone marrow trephine biopsy specimens from 24 patients with chronic granulocytic leukaemia were studied to identify bone marrow changes that suggest incipient or impending blast transformation. In the chronic phase of chronic granulocytic leukaemia, blasts and promyelocytes were seen predominantly in the paratrabecular and perivascular regions, while myelocytes, metamyelocytes and segmented polymorphs were seen predominantly in the central intertrabecular marrow space. The patients were divided into two equal groups according to the degree of perivascular and paratrabecular infiltration: those with minimal (one to three layers of blasts and promyelocytes) and those with marked (four to eight layers of blasts and promyelocytes) infiltration. Ten of the 12 patients in the former group did not develop blast transformation and remained in the chronic phase during a 32- to 84-week follow-up period, whereas nine of the 12 patients in the latter group developed blast transformation, with six undergoing transformation within the first 26 weeks. These findings suggest that the histomorphological pattern of bone marrow changes in chronic granulocytic leukaemia may be useful in recognizing a subset of chronic granulocytic leukaemia patients undergoing blast transformation in the ensuing 6 months.
A Islam
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histopathology     Volume:  12     ISSN:  0309-0167     ISO Abbreviation:  Histopathology     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-10-20     Completed Date:  1988-10-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  633-9     Citation Subset:  IM    
Department of Medical Oncology, Roswell Park Memorial Institute, Buffalo, NY 14263.
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MeSH Terms
Bone Marrow / blood supply,  pathology*
Cell Count
Cell Transformation, Neoplastic*
Leukemia, Myeloid / diagnosis*,  pathology

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