Document Detail


Prediction of functional recovery of 60-minute warm ischemic hearts from asphyxiated canine non-heart-beating donors.
MedLine Citation:
PMID:  16507429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cardiac function of non-heart-beating donors (NHBDs) is uncertain due to severe myocardial damage. We developed an isolated myocardial perfusion system to resuscitate NHBD hearts and attempted to predict functional recovery of 60-minute warm ischemic hearts by analyzing systolic and diastolic functions. METHODS: Hypoxic cardiac arrest was induced in 8 mongrel dogs without any pre-treatments. After 60-minute ischemia, intracoronary microthrombi were flushed out by retrograde blood cardiopledia with tissue-type plasminogen activator. Coronary arteries were initially perfused from the aortic root with tepid hyperkalemic blood (20 mmol/liter) at low pressure (20 mm Hg) for the first 60 minutes and then with normothermic blood for the next 60 minutes. After 120 minutes of reperfusion, pre-load was increased for ejection against an after-load of 80 mm Hg. Pressure-volume loops were recorded to obtain the end-systolic pressure-volume relationship (ESPVR) and end-diastolic pressure-volume relationship (EDPVR). Stroke volume at a given pre-load was calculated from averaged ESPVR, EDPVR and after-load identical to an averaged baseline value. The Frank-Starling relationship was obtained and cardiac status was classified according to Forrester's hemodynamic sub-set. RESULTS: End-systolic elastance decreased significantly to about 60% of baseline and the time constant of isovolumic relaxation was prolonged significantly by about 20%. Cardiac index was decreased to about 50% and cardiac status was classified in the Forrester III or IV sub-set. CONCLUSIONS: The extent of functional recovery of NHBD hearts is predictable by cardiac output. Although 120 minutes of recovery time may be short for 60-minute ischemic damage, this system may be feasible to predict post-transplant cardiac function before transplantation.
Authors:
Masanori Hirota; Kozo Ishino; Ichiro Fukumasu; Kazuhiro Yoshida; Satoshi Mohri; Juichiro Shimizu; Fumihiko Kajiya; Shunji Sano
Related Documents :
3249269 - Effect of heart rate on the end-systolic wall stress-mean velocity of circumferential f...
9813519 - Effects of nicardipine on ventriculo-arterial coupling in humans.
16428349 - Single-beat estimation of end-diastolic pressure-volume relationship: a novel method wi...
6831669 - Influence of atrial systole on the frank-starling relation and the end-diastolic pressu...
23172929 - Substantial reduction in single sympathetic nerve firing after renal denervation in pat...
2050999 - Reduced cardiovascular responsiveness to exercise-induced sympathoadrenergic stimulatio...
11914109 - Advanced analysis of spontaneous baroreflex sensitivity, blood pressure and heart rate ...
10743369 - Prevalence, awareness, treatment and control of hypertension in an elderly community-ba...
18567219 - Relationships between personality and time-related strains.
Publication Detail:
Type:  Journal Article     Date:  2006-01-25
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  25     ISSN:  1557-3117     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-01     Completed Date:  2006-06-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  339-44     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan. mhirota@md.okayama-u.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Dogs
Heart Arrest / chemically induced
Heart Arrest, Induced / methods
Heart Transplantation
Myocardial Ischemia / physiopathology*
Myocardial Reperfusion / methods*
Organ Preservation / methods*
Ventricular Function, Left / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prevalence and prognostic significance of anemia in patients with congestive heart failure treated w...
Next Document:  Longitudinal assessment of psychological functioning in children after heart or heart-lung transplan...