| Prediction of fetal lung maturity from near-infrared spectra of amniotic fluid. | |
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MedLine Citation:
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PMID: 9184953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to attempt to correlate the quantitative data obtained from the near-infrared (near-IR) spectra of amniotic fluid with the lecithin/sphingomyelin (L/S) ratio determined from thin layer chromatographic analysis on the same samples, in order to establish the feasibility of near-IR spectroscopy as an alternate method for the prediction of fetal lung development. METHODS: Samples of amniotic fluid were obtained by amniocentesis from 52 patients between the 26th and 41st week of pregnancy. About 350 microliters of amniotic fluid was required to record the near-IR spectrum over the entire spectral range between 400 and 2500 nm using a commercial spectrometer. The L/S ratio was determined independently by thin layer chromatography (TLC) for each sample. For correlating the infrared spectra with the TLC-based L/S ratios, a partial least squares analysis was used. RESULTS: The L/S ratios predicted from the near-IR spectra of amniotic fluid were highly correlated and in excellent agreement with those determined by TLC (r = 0.91). CONCLUSION: Near-IR spectroscopy has the potential to become an alternate method to TLC for prediction of fetal pulmonary maturity. |
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Authors:
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K Z Liu; M K Ahmed; T C Dembinski; H H Mantsch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 57 ISSN: 0020-7292 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-08-21 Completed Date: 1997-08-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: IRELAND |
Other Details:
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Languages: eng Pagination: 161-8 Citation Subset: IM |
Affiliation:
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Institute for Biodiagnostics, National Research Council of Canada, Manitoba, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniotic Fluid / chemistry* Feasibility Studies Female Fetal Organ Maturity Gestational Age Humans Lung / embryology* Phosphatidylcholines / analysis Predictive Value of Tests Pregnancy Prenatal Diagnosis / methods* Sensitivity and Specificity Spectroscopy, Near-Infrared* Sphingomyelins / analysis |
| Chemical | |
Reg. No./Substance:
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0/Phosphatidylcholines; 0/Sphingomyelins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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