Document Detail

Prediction of extubation outcome in infants using the tension time index.
MedLine Citation:
PMID:  21097837     Owner:  NLM     Status:  In-Data-Review    
Objective Approximately one-third of ventilated infants fail extubation. The objective of this study was to determine whether assessment of the load relative to the capacity of respiratory muscles by measurement of the tension time index (TTI) successfully predicted extubation outcome in infants. Design Prospective study. Setting Tertiary neonatal intensive care unit. Patients Twenty ventilated infants, with a median gestational age of 31 (range 24-39) weeks, were studied at a median postnatal age of 2.5 (range 1-37) days. Interventions The diaphragm tension time index (TTdi) was derived from measurements of transdiaphragmatic pressure using a dual-pressure transducer tipped catheter. The respiratory muscle tension time index (TTmus) was derived from non-invasive airway pressure measurements. Measurements were made within the 6 h prior to extubation. Main outcome measures Extubation failure was defined as the need for reintubation within 48 h of extubation. Results Five infants failed extubation; their median TTdi (p=0.001) and TTmus (p=0.001) were significantly higher than those of the successfully extubated infants. A TTdi of >0.15 and a TTmus of >0.18 were 100% sensitive and 100% specific in predicting extubation failure Conclusion In ventilated infants, invasive and non-invasive measurements of the TTI could provide an accurate prediction of extubation outcome.
Andrew Currie; Deena-Shefali Patel; Gerrard F Rafferty; Anne Greenough
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Publication Detail:
Type:  Journal Article     Date:  2010-11-20
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  96     ISSN:  1468-2052     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F265-9     Citation Subset:  AIM; IM    
Department of Child Health, 4th Floor Golden Jubilee Wing, King's College Hospital, London SE5 9RS, UK;
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