| Prediction of efficacy of anti-TNF biologic agent, infliximab, for rheumatoid arthritis patients using a comprehensive transcriptome analysis of white blood cells. | |
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MedLine Citation:
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PMID: 19577537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Introduction of biologics, such as infliximab, to the therapy of rheumatoid arthritis (RA) patients has revolutionized the treatment of this disease. However, biomarkers for predicting the efficacy of the drug at an early phase of treatment for selecting real responders have not been found. We here present predictive markers based on a thorough transcriptome analysis of white blood cells from RA patients. RNA from whole blood cells of consecutive 42 patients before the first infusion was analyzed with microarrays for training studies. Samples from the subsequent 26 consecutive patients were used for a prospective study. We categorized the results into no inflammation and residual inflammation groups using the serum C-reactive protein (CRP) level at 14weeks after the first infusion. The accuracy of prediction in our study was 65.4%. |
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Authors:
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Motohiko Tanino; Ryo Matoba; Seiji Nakamura; Hideto Kameda; Kouichi Amano; Toshitsugu Okayama; Hayato Nagasawa; Katsuya Suzuki; Kenichi Matsubara; Tsutomu Takeuchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-03 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 387 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-11 Completed Date: 2009-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 261-5 Citation Subset: IM |
Affiliation:
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DNA Chip Research Inc, Yokohama 230-0045, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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pharmacology*,
therapeutic use Antirheumatic Agents / pharmacology*, therapeutic use Arthritis, Rheumatoid / drug therapy, genetics* C-Reactive Protein / analysis Gene Expression / drug effects Gene Expression Profiling Humans Leukocytes / drug effects*, metabolism Tumor Necrosis Factor-alpha / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antirheumatic Agents; 0/Tumor Necrosis Factor-alpha; 0/infliximab; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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