Document Detail


Prediction of early kidney transplant rejection by a crossmatch with donor skin.
MedLine Citation:
PMID:  2688207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immunofluorescence staining of donor skin with recipient serum was performed in 25 patients undergoing kidney transplantation. Transplants were performed when cytotoxicity T cell crossmatches with long incubation and with antiglobulin enhancement were negative. In 20 patients the skin crossmatch was negative and all had an uneventful course. In 5 other recipients, the crossmatch with skin was positive and all developed severe rejection 1-8 days after transplantation. The correlation between skin crossmatch and early rejection was statistically highly significant (P less than 0.00001). Rejection in the skin-crossmatch-positive group led to graft loss in 3, and chronic rejection with poor residual function in the other 2 patients. Serum creatinine at one month was in the 2.6-5.0 mg/dl range in these two patients, while in the group with negative skin crossmatches 15 had serum creatinine levels of less than 1.6, and 5 were in the 1.6-2.5 mg/dl range. Although the nature of the skin antigen is unknown, it appears that this crossmatch procedure was highly accurate in predicting early kidney transplant rejection.
Authors:
J R Moraes; C Pettaway; P Stastny
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Transplantation     Volume:  48     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-01-22     Completed Date:  1990-01-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  951-2     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235.
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MeSH Terms
Descriptor/Qualifier:
Fluorescent Antibody Technique
Graft Rejection*
Histocompatibility Testing*
Humans
Kidney Transplantation*
Skin / immunology*
Grant Support
ID/Acronym/Agency:
P01-AI23271/AI/NIAID NIH HHS; P50-AR39169/AR/NIAMS NIH HHS; R01-AI21278/AI/NIAID NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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