| Prediction of early, intermediate and late pre-eclampsia from maternal factors, biophysical and biochemical markers at 11-13 weeks. | |
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MedLine Citation:
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PMID: 21210481 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To develop models for prediction of pre-eclampsia (PE) based on maternal factors and biophysical and biochemical markers at 11-13 weeks' gestation. METHODS: Screening study of singleton pregnancies at 11-13 weeks including 752 (2.2%) that subsequently developed PE and 32,850 that were unaffected by PE. Models were developed for the prediction of early PE, requiring delivery before 34 weeks, intermediate PE with delivery at 34-37 weeks and late PE delivering after 37 weeks. The data used for the models were firstly, maternal characteristics and history, uterine artery pulsatility index, mean arterial pressure and serum pregnancy-associated plasma protein-A obtained from the screening study and secondly, maternal serum or plasma concentration of placental growth factor, placental protein-13, inhibin-A, activin-A, soluble endoglin, pentraxin-3 and P-selectin obtained from case-control studies. RESULTS: In screening for PE by maternal factors only at a fixed false positive rate of 5%, the estimated detection rates were 33.0% for early PE, 27.8% for intermediate PE and 24.5% for late PE. The respective detection rates in screening by a combination of maternal factors, biophysical and biochemical markers were 91.0, 79.4 and 60.9%. CONCLUSIONS: Effective prediction of PE can be achieved at 11-13 weeks' gestation. |
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Authors:
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Ranjit Akolekar; Argyro Syngelaki; Rita Sarquis; Mona Zvanca; Kypros H Nicolaides |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prenatal diagnosis Volume: 31 ISSN: 1097-0223 ISO Abbreviation: Prenat. Diagn. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-06 Completed Date: 2011-04-18 Revised Date: 2011-09-06 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 66-74 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
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Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / analysis* Blood Pressure Continental Population Groups Delivery, Obstetric Female Gestational Age* Humans Logistic Models Maternal Age Pre-Eclampsia / diagnosis* Pregnancy Pregnancy-Associated Plasma Protein-A / analysis Pulsatile Flow Uterine Artery / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
| Comments/Corrections | |
Erratum In:
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Prenat Diagn. 2011 Aug;31(8):832 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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