Document Detail


Prediction of coronary heart disease by erectile dysfunction in men referred for nuclear stress testing.
MedLine Citation:
PMID:  16432089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Recent evidence suggests a strong link between erectile dysfunction (ED) and atherosclerotic vascular disease. Stress myocardial perfusion single-photon emission computed tomography (MPS) is a widely used noninvasive imaging modality that allows diagnosis of coronary heart disease and stratification of cardiovascular risk. We sought to determine the relationship between ED and coronary heart disease in men referred for MPS. METHODS: A total of 221 men referred for MPS were prospectively screened for ED with a validated questionnaire. Patient characteristics, MPS findings, and exercise results were correlated with ED. RESULTS: Erectile dysfunction was present in 54.8% of the patients. Patients with ED exhibited more severe coronary heart disease (MPS summed stress score >8) (43.0% vs 17.0%; P<.001) and left ventricular dysfunction (left ventricular ejection fraction <50%) (24.0% vs 11.0%; P=.01) than those without ED. Erectile dysfunction was associated with a shorter exercise time (8.0 vs 10.1 minutes; P<.001) and lower Duke treadmill score (4.4 vs 8.4; P<.001). Multivariate analysis showed ED to be an independent predictor of severe coronary heart disease (odds ratio, 2.50; 95% confidence interval, 1.24-5.04; P = .01) and high-risk MPS findings (summed stress score >8, transient ischemic dilation, or left ventricular ejection fraction <35%) (odds ratio, 2.86; 95% confidence interval, 1.43-5.74; P = .003). CONCLUSIONS: Erectile dysfunction is common in men referred for MPS, is associated with markers of adverse cardiovascular prognosis, and is an independent predictor of severe coronary heart disease and high-risk MPS findings. These results suggest that questioning about sexual function may be a useful tool for stratifying risk in individuals with suspected coronary heart disease.
Authors:
James K Min; Kim A Williams; Tochi M Okwuosa; George W Bell; Michael S Panutich; R Parker Ward
Related Documents :
18492249 - Prognostic implications of negative dobutamine stress echocardiography in african ameri...
11696689 - Functional and prognostic significance of silent ischemia during dobutamine stress echo...
15534059 - Reduced oxidative metabolic response in dysfunctional myocardium with preserved glucose...
16490449 - Comparison of heart rate reserve versus 85% of age-predicted maximum heart rate as a me...
15982489 - Usefulness of strain rate imaging in detecting ischemic myocardium during dobutamine st...
10925349 - Lack of clinically significant cardiac dysfunction during intermediate dobutamine doses...
7769439 - Quantitative myocardial spect for infarct sizing: feasibility of a multicenter trial ev...
22562999 - Safety and efficacy of intracoronary adenosine administration in patients with acute my...
123409 - Electrocardiographic evidence of left ventricular hypertrophy in otherwise normal child...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of internal medicine     Volume:  166     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-24     Completed Date:  2006-02-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  201-6     Citation Subset:  AIM; IM    
Affiliation:
Section of Cardiology, Department of Medicine, The University of Chicago Hospitals, Chicago, Ill 60637, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Age Distribution
Aged
Aged, 80 and over
Comorbidity
Coronary Artery Disease / drug therapy,  epidemiology*,  radionuclide imaging*
Erectile Dysfunction / diagnosis,  epidemiology*
Exercise Test / methods*
Humans
Incidence
Logistic Models
Male
Middle Aged
Multivariate Analysis
Predictive Value of Tests
Probability
Prospective Studies
Questionnaires
Risk Assessment
Severity of Illness Index
Tomography, Emission-Computed, Single-Photon*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical depression and risk of out-of-hospital cardiac arrest.
Next Document:  Predictors and prevalence of erectile dysfunction in a racially diverse population.