Document Detail

Prediction of coronary heart disease by erectile dysfunction in men referred for nuclear stress testing.
MedLine Citation:
PMID:  16432089     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recent evidence suggests a strong link between erectile dysfunction (ED) and atherosclerotic vascular disease. Stress myocardial perfusion single-photon emission computed tomography (MPS) is a widely used noninvasive imaging modality that allows diagnosis of coronary heart disease and stratification of cardiovascular risk. We sought to determine the relationship between ED and coronary heart disease in men referred for MPS. METHODS: A total of 221 men referred for MPS were prospectively screened for ED with a validated questionnaire. Patient characteristics, MPS findings, and exercise results were correlated with ED. RESULTS: Erectile dysfunction was present in 54.8% of the patients. Patients with ED exhibited more severe coronary heart disease (MPS summed stress score >8) (43.0% vs 17.0%; P<.001) and left ventricular dysfunction (left ventricular ejection fraction <50%) (24.0% vs 11.0%; P=.01) than those without ED. Erectile dysfunction was associated with a shorter exercise time (8.0 vs 10.1 minutes; P<.001) and lower Duke treadmill score (4.4 vs 8.4; P<.001). Multivariate analysis showed ED to be an independent predictor of severe coronary heart disease (odds ratio, 2.50; 95% confidence interval, 1.24-5.04; P = .01) and high-risk MPS findings (summed stress score >8, transient ischemic dilation, or left ventricular ejection fraction <35%) (odds ratio, 2.86; 95% confidence interval, 1.43-5.74; P = .003). CONCLUSIONS: Erectile dysfunction is common in men referred for MPS, is associated with markers of adverse cardiovascular prognosis, and is an independent predictor of severe coronary heart disease and high-risk MPS findings. These results suggest that questioning about sexual function may be a useful tool for stratifying risk in individuals with suspected coronary heart disease.
James K Min; Kim A Williams; Tochi M Okwuosa; George W Bell; Michael S Panutich; R Parker Ward
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of internal medicine     Volume:  166     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-24     Completed Date:  2006-02-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  201-6     Citation Subset:  AIM; IM    
Section of Cardiology, Department of Medicine, The University of Chicago Hospitals, Chicago, Ill 60637, USA.
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MeSH Terms
Age Distribution
Aged, 80 and over
Coronary Artery Disease / drug therapy,  epidemiology*,  radionuclide imaging*
Erectile Dysfunction / diagnosis,  epidemiology*
Exercise Test / methods*
Logistic Models
Middle Aged
Multivariate Analysis
Predictive Value of Tests
Prospective Studies
Risk Assessment
Severity of Illness Index
Tomography, Emission-Computed, Single-Photon*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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