Document Detail

Prediction of cervical response to prostaglandin E2 using fetal fibronectin.
MedLine Citation:
PMID:  10577614     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To determine whether presence of fetal fibronectin in cervico-vaginal secretions at term will predict the cervical response to prostaglandin E2 (PGE2) pessaries and successful induction of labor amongst subjects with unfavorable cervices. METHODS: Cervico-vaginal secretion was tested for the presence of fetal fibronectin prior to cervical ripening with PGE2 pessaries in women with a singleton term or post-term pregnancy undergoing induction of labor. The total number of PGE2 pessaries, interval from induction to labor and induction to delivery, latent phase and active phase of labor and cesarean section rate were compared. RESULTS: Women with fetal fibronectin in their cervico-vaginal secretion had better cervical response to PGE2 pessaries and required fewer doses for induction of labor and they took a shorter time interval from induction to delivery. They tend to have a lower cesarean section rate but the figures did not reach statistical significance. CONCLUSIONS: The presence of fetal fibronectin from cervico-vaginal secretions in subjects with a Bishop score <5 is predictive of a favorable response to induction by prostaglandin pessary
W H Tam; S M Tai; M S Rogers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  78     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-09     Completed Date:  1999-12-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  861-5     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.
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MeSH Terms
Cervical Ripening / drug effects
Cervix Uteri / drug effects*,  secretion
Cesarean Section
Dinoprostone / administration & dosage,  pharmacology*
Fibronectins / analysis*
Labor, Induced*
Oxytocics / administration & dosage,  pharmacology*
Prospective Studies
Vagina / secretion
Reg. No./Substance:
0/Fibronectins; 0/Oxytocics; 363-24-6/Dinoprostone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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