| Prediction of carotid plaques in hypertensive patients by risk factors, left ventricular hypertrophy, and epicardial adipose tissue thickness. | |
| | |
MedLine Citation:
|
PMID: 22427251 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Hypertension and other risk factors (RFs) predispose to carotid plaques (CPs). An association between left ventricular hypertrophy (LVH) or epicardial adipose tissue (EAT) and CPs has also been reported. The aim of the study was to evaluate whether the assessment of LVH and EAT thickness, beyond RFs, would be of additive value in predicting CPs in hypertensive subjects. We studied 548 hypertensive patients aged ≥50 years without carotid bruit. LVH and CPs were evaluated and defined according to standard criteria. EAT was measured by echocardiography above the free wall of the right ventricle at end diastole. The presence of LVH and EAT thickness above the median value (3.9 mm) together significantly increased prevalence of CPs in subjects with 0-1 risk factor, but not in those with ≥2 RFs who showed high prevalence of CPs independently of LVH and/or EAT. Receiver operating characteristic curve analysis showed that the addition of LVH and higher EAT thickness together significantly improved prediction of CPs in patients with 0-1 risk factor. Indeed, the area under the curve improved from 0.63 (0.56-0.69) to 0.73 (0.67-0.79), which was significantly higher (p < 0.05). In patients with ≥2 RFs, the addition of LVH and EAT did not significantly improve prediction of CPs. This study shows that the presence of LVH and higher EAT thickness together improves prediction of CPs in hypertensive patients with 0-1 risk factor and that those with ≥2 RFs show high prevalence of CPs independently of LVH and/or EAT. |
| | |
Authors:
|
Sante D Pierdomenico; Mariantonietta Mancini; Chiara Cuccurullo; Maria D Guglielmi; Anna M Pierdomenico; Marta Di Nicola; Silvio Di Carlo; Domenico Lapenna; Franco Cuccurullo |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-3-17 |
Journal Detail:
|
Title: Heart and vessels Volume: - ISSN: 1615-2573 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-3-19 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Dipartimento di Medicina e Scienze dell'Invecchiamento, Università "Gabriele d'Annunzio", Patologia Medica, Policlinico "Santissima Annunziata", Via dei Vestini, 66013, Chieti Scalo (Chieti), Italy, pierdomenico@unich.it. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Generation and Comparative Characterization of Glycosylated and Aglycosylated Human IgG1 Antibodies.
Next Document: Lipid-lowering and anti-inflammatory effect of ezetimibe in hyperlipidemic patients with coronary ar...