Document Detail

Prediction of bone strength of distal forearm using radius bone mineral density and phalangeal speed of sound.
MedLine Citation:
PMID:  10773595     Owner:  NLM     Status:  MEDLINE    
This investigation compares quantitative ultrasound (QUS) measurement of the phalanges with peripheral quantitative computed tomography (pQCT) and dual X-ray absorptiometry (DXA) measurement of the forearm, to estimate the strength of the distal radius in 13 cadaveric forearms. The cadavers were scanned at the distal radius by pQCT and DXA for bone mineral density (BMD) and at the approximate phalanges by QUS for speed of sound (SOS). The distal radii were subjected to a simulated Colles fracture produced with a materials testing machine. The load at which the distal radius was fractured was considered as a representation of bone strength. The bone strength correlated significantly with SOS at different phalanges (r = 0.63-0.72), BMD at different regions of interest by DXA (r = 0.67-0.75), and cortical BMD at different sites by pQCT (r = 0.61-0.67). Standard stepwise regression analysis showed that adding phalangeal SOS into forearm densitometric variables significantly enhanced the statistical power for prediction of the strength of the distal radius. Our results suggest that, for assessment of site-specific distal forearm strength, QUS measurement of the phalanges is comparable to forearm densitometry. Phalangeal QUS may add clinical value if distal forearm strength has a high priority.
C Wu; D Hans; Y He; B Fan; C F Njeh; P Augat; J Richards; H K Genant
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Bone     Volume:  26     ISSN:  8756-3282     ISO Abbreviation:  Bone     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-05-31     Completed Date:  2000-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8504048     Medline TA:  Bone     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  529-33     Citation Subset:  IM; S    
Osteoporosis and Arthritis Research Group, Department of Radiology, University of California, San Francisco, San Francisco, CA 94117-0784, USA.
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MeSH Terms
Aged, 80 and over
Fingers / physiology*,  radiography,  ultrasonography
Fractures, Bone
Middle Aged
Radius / physiology*,  radiography,  ultrasonography
Tomography, X-Ray Computed

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