Document Detail

Prediction of auditory nerve survival in humans using the electrical auditory brainstem response.
MedLine Citation:
PMID:  1789304     Owner:  NLM     Status:  MEDLINE    
This investigation studied the electrical auditory brainstem response (EABR) input-output functions in three groups of patients: individuals with normal auditory neural systems; patients with acquired, profound sensorineural hearing loss; and patients with congenital, profound sensorineural hearing loss. Each input-output function was obtained in the operating room under general anesthesia and with the patient paralyzed to eliminate myogenic contamination. In contrast to the acoustically elicited ABR, the EABR waveforms were characterized by a dominant early wave corresponding in latency to wave II. This wave was much larger and often appeared at lower stimulus intensities than wave V. The results, plotted according to rate of growth for waves II and V, showed that normal subjects generally had larger, more robust early waves than either hearing impaired group. Little difference was noted in the amplitudes or rates of growth for wave V among the three groups. Based on these observations, we concluded that the EABR demonstrated differences in the way normal and impaired systems respond to electrical stimulation. In addition, the EABR may be useful in providing a qualitative prediction of neural survival into broad categories of many surviving neurons versus a marked reduction in ganglion/neuronal density.
R C Fifer; M A Novak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of otology     Volume:  12     ISSN:  0192-9763     ISO Abbreviation:  Am J Otol     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-03-23     Completed Date:  1992-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909513     Medline TA:  Am J Otol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  350-6     Citation Subset:  IM    
Department of Pediatrics, University of Miami School of Medicine, Florida 33101.
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MeSH Terms
Child, Preschool
Evoked Potentials, Auditory, Brain Stem* / physiology
Hearing Loss, Sensorineural / congenital,  physiopathology*
Middle Aged
Vestibulocochlear Nerve / physiology,  physiopathology*
Comment In:
Am J Otol. 1992 Jul;13(4):381-2   [PMID:  1415507 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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