Document Detail


Prediction of auditory nerve survival in humans using the electrical auditory brainstem response.
MedLine Citation:
PMID:  1789304     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This investigation studied the electrical auditory brainstem response (EABR) input-output functions in three groups of patients: individuals with normal auditory neural systems; patients with acquired, profound sensorineural hearing loss; and patients with congenital, profound sensorineural hearing loss. Each input-output function was obtained in the operating room under general anesthesia and with the patient paralyzed to eliminate myogenic contamination. In contrast to the acoustically elicited ABR, the EABR waveforms were characterized by a dominant early wave corresponding in latency to wave II. This wave was much larger and often appeared at lower stimulus intensities than wave V. The results, plotted according to rate of growth for waves II and V, showed that normal subjects generally had larger, more robust early waves than either hearing impaired group. Little difference was noted in the amplitudes or rates of growth for wave V among the three groups. Based on these observations, we concluded that the EABR demonstrated differences in the way normal and impaired systems respond to electrical stimulation. In addition, the EABR may be useful in providing a qualitative prediction of neural survival into broad categories of many surviving neurons versus a marked reduction in ganglion/neuronal density.
Authors:
R C Fifer; M A Novak
Related Documents :
21852974 - Signalosomes in the brain: relevance in the development of certain neuropathologies suc...
16404044 - Visualization of a stationary cpg-revealing spinal wave.
515684 - Frequency composition of brain-stem auditory evoked potentials.
3346014 - Turner's syndrome: a qualitative and quantitative analysis of eeg background activity.
18602934 - Functional reorganization of the human auditory pathways following hemispherectomy: an ...
818344 - Sensory jacksonian seizures.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of otology     Volume:  12     ISSN:  0192-9763     ISO Abbreviation:  Am J Otol     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-03-23     Completed Date:  1992-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909513     Medline TA:  Am J Otol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  350-6     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Miami School of Medicine, Florida 33101.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
Child, Preschool
Evoked Potentials, Auditory, Brain Stem* / physiology
Female
Hearing Loss, Sensorineural / congenital,  physiopathology*
Humans
Male
Middle Aged
Vestibulocochlear Nerve / physiology,  physiopathology*
Comments/Corrections
Comment In:
Am J Otol. 1992 Jul;13(4):381-2   [PMID:  1415507 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Practical method of reporting test results in neurotologic disorders.
Next Document:  Age-related changes in binaural processing: I. Evoked potential findings.