| Prediction of asthma in symptomatic preschool children using exhaled nitric oxide, Rint and specific IgE. | |
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MedLine Citation:
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PMID: 20805175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE: For clinicians it remains very difficult to predict whether preschool children with symptoms suggestive of asthma will develop asthma in later childhood. OBJECTIVE: To investigate whether measurement of fraction of exhaled nitric oxide (FE(NO)), interrupter resistance (Rint) or specific immunoglobulin E (IgE) in 4-year-old children with suggestive symptoms can predict asthma symptoms up to age 8 years. METHODS: Children were recruited from the PIAMA birth cohort. All children with symptoms suggestive of asthma at age 3 or 4 years, who were invited for medical examination at age 4 (n=848), were eligible. Associations of FE(NO) (n=308), Rint (n=482) and specific IgE (n=380) at 4 years with wheezing and asthma at the ages of 5-8 years were assessed using repeated measurement analyses. The added predictive value of these objective tests was then investigated by including parameters for clinical history in the model. RESULTS: FE(NO) and specific IgE measured at 4 years were associated with wheezing and asthma at 8 years. Both tests also remained significant predictors after mutual adjustment and adjustment for clinical history: OR on wheezing at 8 years for FE(NO) ((10)log-scale, per IQR) 1.6 (95% CI 1.1 to 2.2) and for specific IgE 2.8 (95% CI 1.9 to 4.1). Rint was significantly associated with wheezing at age 6, but not at 7 and 8 years. CONCLUSIONS: In preschool children with symptoms suggestive of asthma, both FE(NO) and specific IgE measured at age 4, but not Rint, improved the prediction of asthma symptoms until the age of 8 years, independent of clinical history. |
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Authors:
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Daan Caudri; Alet H Wijga; Maarten O Hoekstra; Marjan Kerkhof; Gerard H Koppelman; Bert Brunekreef; Henriette A Smit; Johan C de Jongste |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Thorax Volume: 65 ISSN: 1468-3296 ISO Abbreviation: Thorax Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-31 Completed Date: 2010-10-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417353 Medline TA: Thorax Country: England |
Other Details:
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Languages: eng Pagination: 801-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics/Respiratory Medicine, Erasmus University, Rotterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance
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physiology* Asthma / diagnosis* Biological Markers / metabolism Breath Tests / methods Child Child, Preschool Disease Progression Female Follow-Up Studies Humans Immunoglobulin E / biosynthesis* Male Nitric Oxide / metabolism* Predictive Value of Tests Prognosis Respiratory Sounds / diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 10102-43-9/Nitric Oxide; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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