Document Detail

Prediction of adverse pregnancy outcomes by combinations of first and second trimester biochemistry markers used in the routine prenatal screening of Down syndrome.
MedLine Citation:
PMID:  20440736     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the associations between four defined adverse pregnancy outcomes and levels of first and second trimester maternal serum markers focusing in particular on how well combinations of markers predict these adverse outcomes. METHODS: This was a retrospective review of associations between first and second trimester serum markers and adverse pregnancy outcomes among 141 698 women who underwent prenatal screening for Down syndrome in Ontario, Canada. Detection rates (DR), false positive rates (FPR), and odds ratios were estimated using both single and combinations of markers for the adverse outcomes defined. RESULTS: Women with decreased second trimester unconjugated oestriol (uE3), deceased first trimester maternal serum pregnancy-associated plasma protein A (PAPP-A), increased second trimester serum alpha fetoprotein (AFP), or increased second trimester total human chorionic gonadotrophin (hCG) were at greater risk of developing adverse pregnancy outcomes. At a 5% FPR, combinations of these markers predicted at best 33.3% of fetal loss and 31.5% of preterm births (PTB) before 32 weeks of gestation. CONCLUSION: There are significant associations between the levels of first and second trimester serum markers and adverse obstetric outcomes. However, even combinations of these markers can only predict adverse obstetric outcomes with modest accuracy.
Tianhua Huang; Barry Hoffman; Wendy Meschino; John Kingdom; Nanette Okun
Related Documents :
7514056 - Maternal serum markers. estimation of the risk of down's syndrome: a prospective study.
9363186 - Pulmonary function during pregnancy in cystic fibrosis: implications for counseling.
19266536 - Identification of second trimester screen positive pregnancies at increased risk for co...
17003556 - First trimester down's syndrome screening shows high detection rate for trisomy 21, but...
7258696 - Prenatal and postnatal development of the cervical portion of the spine in the short-fi...
871736 - Spontaneous premature birth in twin pregnancy.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  30     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  471-7     Citation Subset:  IM    
Genetics Program, North York General Hospital, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Markers / blood
Chorionic Gonadotropin / blood
Down Syndrome / blood
Estriol / blood
False Positive Reactions
Fetal Death / blood*
Pre-Eclampsia / blood*
Predictive Value of Tests
Pregnancy Trimester, First / blood*
Pregnancy Trimester, Second / blood*
Pregnancy-Associated Plasma Protein-A / analysis
Premature Birth / blood*
ROC Curve
Retrospective Studies
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin; 0/alpha-Fetoproteins; 50-27-1/Estriol; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Training in cordocentesis: the first 50 case experience with and without a cordocentesis training mo...
Next Document:  Postmarital follow-up survey on high risk patients subjected to premarital screening program in Saud...