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Prediction of Small-for-Gestation Neonates from Biophysical and Biochemical Markers at 11-13 Weeks.
MedLine Citation:
PMID:  21079385     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective: To develop a model for prediction of small-for-gestational age (SGA) neonates in the absence of preeclampsia (PE) based on maternal factors and biophysical and biochemical markers at 11-13 weeks' gestation. Methods: Screening study in 1,536 SGA and 31,314 non-SGA pregnancies based on maternal characteristics, fetal nuchal translucency (NT) thickness, serum pregnancy-associated plasma protein-A (PAPP-A) and free β-human chorionic gonadotrophin (β-hCG). We also measured mean arterial pressure (MAP), uterine artery pulsatility index (PI) and performed case-control studies for measurement of maternal serum concentration of placental growth factor (PLGF), placental protein 13 (PP13) and A Disintegrin And Metalloprotease (ADAM12). Regression analysis was used to develop a model for the prediction of SGA. Results: In the SGA group, uterine artery PI and MAP were increased and serum PAPP-A, free β-hCG, PLGF, PP13, and ADAM12 and fetal NT were decreased. At a false positive rate of 10%, the estimated detection rate by a combination of maternal factors and biophysical and biochemical markers at 11-13 weeks was 73% for SGA requiring delivery before 37 weeks and 46% for those delivering at term. Conclusions: Half of pregnancies with SGA neonates in the absence of PE could potentially be identified at 11-13 weeks.
Authors:
George Karagiannis; Ranjit Akolekar; Rita Sarquis; David Wright; Kypros H Nicolaides
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Publication Detail:
Type:  Journal Article     Date:  2010-11-16
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  29     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  148-54     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Affiliation:
Harris Birthright Research Centre of Fetal Medicine, King's College Hospital, London, UK.
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