Document Detail

Prediction of preeclampsia by combining serum histidine-rich glycoprotein and uterine artery Doppler.
MedLine Citation:
PMID:  22895448     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Preeclampsia is associated with both maternal and perinatal morbidity and mortality. Histidine-rich glycoprotein (HRG) is a protein interacting with angiogenesis, coagulation, and inflammatory responses, processes known to be altered in preeclamptic pregnancies. Significantly lower levels of HRG have been demonstrated as early as in the first trimester in women later developing preeclampsia compared with normal pregnancies. The aim of this study was to investigate whether the combination of HRG and uterine artery Doppler ultrasonography can be used as a predictor of preeclampsia.
METHODS: A total of 175 women were randomly selected from a case-control study; 86 women had an uncomplicated pregnancy and 89 women later developed preeclampsia. Blood samples and pulsatility index (PI) were obtained from both cases and controls in gestational week 14.
RESULTS: HRG levels were significantly lower in women who developed preterm preeclampsia compared with controls, but not for women developing preeclampsia in general. PI was significantly higher in the preeclampsia group compared with controls, especially in preterm preeclampsia. The combination of HRG and PI revealed a sensitivity of 91% and a specificity of 62% for preterm preeclampsia.
CONCLUSIONS: The combination of HRG and uterine artery Doppler may predict preterm preeclampsia in early pregnancy.
Marie Bolin; Anna-Karin Wikström; Eva Wiberg-Itzel; Anna-Karin Olsson; Maria Ringvall; Inger Sundström-Poromaa; Ove Axelsson; Basky Thilaganathan; Helena Åkerud
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-16
Journal Detail:
Title:  American journal of hypertension     Volume:  25     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-05-14     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1305-10     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood
Case-Control Studies
Chi-Square Distribution
Enzyme-Linked Immunosorbent Assay
Gestational Age
Pre-Eclampsia / blood,  diagnosis*,  physiopathology,  ultrasonography
Predictive Value of Tests
Proteins / analysis*
Pulsatile Flow
Sensitivity and Specificity
Ultrasonography, Doppler*
Uterine Artery / physiopathology,  ultrasonography*
Reg. No./Substance:
0/Biological Markers; 0/Proteins; 0/histidine-rich proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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