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Prediction of Preeclampsia: Liver Function Tests during the First 20 Gestational Weeks.
MedLine Citation:
PMID:  23035884     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: To examine whether plasma levels of aspartate transaminase (AST) and alanine transaminase (ALT) during the first 20 weeks of pregnancy can predict preeclampsia in the second half of pregnancy. Methods: The study population included 15010 registered births. Receiver operating characteristic (ROC) curve analysis was used to describe the relationship between different values of AST and ALT during the first 20 weeks of pregnancy in the prediction of preeclampsia. Results: Using ROC curve analyses, elevated ALT levels were significantly associated with both mild preeclampsia (P<0.001) and severe preeclampsia (P=0.032). However, an ALT level of 50IU/L had a sensitivity of only 3.3% (despite a specificity of 97%) in the prediction of severe preeclampsia. While no significant association was noted between AST levels and mild preeclampsia (P=0.669), elevated levels of AST during this period were significantly associated with severe preeclampsia (P=0.027). However, AST of 50IU/L had a sensitivity of only 2.0% (despite a specificity of 98%) in the prediction of severe preeclampsia. Conclusions: Higher levels of the liver enzymes AST and ALT during the first 20 weeks of pregnancy are associated with higher risk for the development of severe preeclampsia in the second half of the pregnancy. Nevertheless, there is no clinical cut-off value that can be practically used for the prediction of preeclampsia.
Authors:
Elad Mei-Dan; Arnon Wiznitzer; Ruslan Sergienko; Mordechai Hallak; Eyal Sheiner
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics & Gynecology, Hillel Yaffe Medical Center, Hadera, Israel.
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