Document Detail


Prediction of motor recovery using initial impairment and fMRI 48 h poststroke.
MedLine Citation:
PMID:  21527788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is substantial interpatient variation in recovery from upper limb impairment after stroke in patients with severe initial impairment. Defining recovery as a change in the upper limb Fugl-Meyer score (ΔFM), we predicted ΔFM with its conditional expectation (i.e., posterior mean) given upper limb Fugl-Meyer initial impairment (FM(ii)) and a putative functional magnetic resonance imaging (fMRI) recovery measure. Patients with first time, ischemic stroke were imaged at 2.5 ± 2.2 days poststroke with 1.5-T fMRI during a hand closure task alternating with rest (fundamental frequency = 0.025 Hz, scan duration = 172 s). Confirming a previous finding, we observed that the prediction of ΔFM by FM(ii) alone is good in patients with nonsevere initial hemiparesis but is not good in patients with severe initial hemiparesis (96% and 16% of the total sum of squares of ΔFM explained, respectively). In patients with severe initial hemiparesis, prediction of ΔFM by the combination of FM(ii) and the putative fMRI recovery measure nonsignificantly increased predictive explanation from 16% to 47% of the total sum of squares of ΔFM explained. The implications of this preliminary negative result are discussed.
Authors:
Eric Zarahn; Leeor Alon; Sophia L Ryan; Ronald M Lazar; Magnus-Sebastian Vry; Cornelius Weiller; Randolph S Marshall; John W Krakauer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-04-28
Journal Detail:
Title:  Cerebral cortex (New York, N.Y. : 1991)     Volume:  21     ISSN:  1460-2199     ISO Abbreviation:  Cereb. Cortex     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-07     Completed Date:  2012-02-22     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9110718     Medline TA:  Cereb Cortex     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2712-21     Citation Subset:  IM    
Affiliation:
The Neurological Institute, New York, NY 10032, USA. eric.zarahn@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Disability Evaluation*
Female
Humans
Magnetic Resonance Imaging*
Male
Middle Aged
Models, Theoretical*
Motor Activity / physiology
Recovery of Function / physiology*
Stroke / physiopathology*
Task Performance and Analysis
Grant Support
ID/Acronym/Agency:
5P50NS049060/NS/NINDS NIH HHS; K02NS048099/NS/NINDS NIH HHS; R01 NS052804/NS/NINDS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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