| Prediction of Codeine Toxicity in Infants and Their Mothers Using a Novel Combination of Maternal Genetic Markers. | |
| | |
MedLine Citation:
|
PMID: 22398969 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Substantial variation exists in response to standard doses of codeine ranging from poor analgesia to life-threatening central nervous system (CNS) depression. We aimed to discover the genetic markers predictive of codeine toxicity by evaluating the associations between polymorphisms in cytochrome P450 2D6 (CYP2D6), UDP-glucuronosyltransferase 2B7 (UGT2B7), P-glycoprotein (ABCB1), mu-opioid receptor (OPRM1), and catechol O-methyltransferase (COMT) genes, which are involved in the codeine pathway, and the symptoms of CNS depression in 111 breastfeeding mothers using codeine and their infants. A genetic model combining the maternal risk genotypes in CYP2D6 and ABCB1 was significantly associated with the adverse outcomes in infants (odds ratio (OR) 2.68; 95% confidence interval (CI) 1.61-4.48; P(trend) = 0.0002) and their mothers (OR 2.74; 95% CI 1.55-4.84; P(trend) = 0.0005). A novel combination of the genetic and clinical factors predicted 87% of the infant and maternal CNS depression cases with a sensitivity of 80% and a specificity of 87%. Genetic markers can be used to improve the outcome of codeine therapy and are also probably important for other opioids sharing common biotransformation pathways. |
| | |
Authors:
|
J Sistonen; P Madadi; C J Ross; M Yazdanpanah; J W Lee; M L A Landsmeer; M Nauta; B C Carleton; G Koren; M R Hayden |
Related Documents
:
|
16921699 - Predictors of poor outcome in neonates with bacterial sepsis admitted to the university... 18972849 - Management of infants and young children with fever without source. 12828589 - Colonization with group b streptococci in pregnancy and outcome of infected neonates in... 10771949 - Endotracheal aspirate cultures in predicting sepsis in ventilated neonates. 2006949 - Can the nonstress test predict congenital sepsis? 2896729 - Maternal screening in prevention of neonatal infections: current status and rationale f... 9131309 - Antenatal and delivery risk factors simultaneously associated with neonatal death and c... 14530859 - Intravenous sildenafil and inhaled nitric oxide: a randomised trial in infants after ca... 1624049 - Vitamin e therapy in retinopathy of prematurity. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-3-07 |
Journal Detail:
|
Title: Clinical pharmacology and therapeutics Volume: - ISSN: 1532-6535 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-3-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1] Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada [2] Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada [3] Institute of Clinical Chemistry, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bridging Strategies for Drug Combinations in Pediatric Indications.
Next Document: Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics.