Document Detail


Prediction of blood pressure changes over time and incidence of hypertension by a genetic risk score in Swedes.
MedLine Citation:
PMID:  23232644     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent Genome-Wide Association Studies (GWAS) have pinpointed different single nucleotide polymorphisms consistently associated with blood pressure (BP) and hypertension prevalence. However, little data exist regarding single nucleotide polymorphisms predicting BP variation over time and hypertension incidence. The aim of this study was to confirm the association of a genetic risk score (GRS), based on 29 independent single nucleotide polymorphisms, with cross-sectional BP and hypertension prevalence and to challenge its prediction of BP change over time and hypertension incidence in >17 000 middle-aged Swedes participating in a prospective study, the Malmö Preventive Project, investigated at baseline and over a 23-year average period of follow-up. The GRS was associated with higher systolic and diastolic BP values both at baseline (β ± SEM, 0.968 ± 0.102 mm Hg and 0.585 ± 0.064 mm Hg; P<1E-19 for both) and at reinvestigation (β ± SEM, 1.333 ± 0.161 mm Hg and 0.724 ± 0.086 mm Hg; P<1E-15 for both) and with increased hypertension prevalence (odds ratio [95% CI], 1.192 [1.140-1.245] and 1.144 [1.107-1.183]; P<1E-15 for both). The GRS was positively associated with change (Δ) in BP (β ± SEM, 0.033 ± 0.008 mm Hg/y and 0.023 ± 0.004 mm Hg/y; P<1E-04 for both) and hypertension incidence (odds ratio [95% CI], 1.110 [1.065-1.156]; P=6.7 E-07), independently from traditional risk factors. The relative weight of the GRS was lower in magnitude than obesity or prehypertension, but comparable with diabetes mellitus or a positive family history of hypertension. A C-statistics analysis does not show any improvement in the prediction of incident hypertension on top of traditional risk factors. Our data from a large cohort study show that a GRS is independently associated with BP increase and incidence of hypertension.
Authors:
Cristiano Fava; Marketa Sjögren; Martina Montagnana; Elisa Danese; Peter Almgren; Gunnar Engström; Peter Nilsson; Bo Hedblad; Gian Cesare Guidi; Pietro Minuz; Olle Melander
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-12-10
Journal Detail:
Title:  Hypertension     Volume:  61     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-03-20     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  319-26     Citation Subset:  IM    
Affiliation:
Department of Clinical Sciences, Lund University, University Hospital of Malmö, Sweden. cristiano.fava@med.lu.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / genetics*
Cohort Studies
Female
Genetic Predisposition to Disease*
Genotype
Humans
Hypertension / epidemiology*,  genetics*
Incidence
Male
Middle Aged
Polymorphism, Single Nucleotide*
Prevalence
Prospective Studies
Sweden / epidemiology
Comments/Corrections
Erratum In:
Hypertension. 2013 May;61(5):e50

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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