| Prediction of Barrett's Esophagus Among Men. | |
| | |
MedLine Citation:
|
PMID: 23318485 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES:Risk factors for Barrett's esophagus include gastroesophageal reflux disease (GERD) symptoms, age, abdominal obesity, and tobacco use. We aimed to develop a tool using these factors to predict the presence of Barrett's esophagus.METHODS:Male colorectal cancer (CRC) screenees were recruited to undergo upper endoscopy, identifying newly diagnosed cases of Barrett's esophagus. Logistic regression models predicting Barrett's esophagus using GERD symptoms alone and together with abdominal obesity, tobacco use, and age were compared.RESULTS:Barrett's esophagus was found in 70 (8.5%) of 822 CRC screenees. Mutually adjusting for other covariates, Barrett's esophagus was associated with weekly GERD (odds ratio (OR)=2.33, 95% confidence interval (CI)=1.34, 4.05), age (OR per 10 years=1.53, 95% CI=1.05, 2.25), waist-to-hip ratio (OR per 0.10=1.44, 95% CI=0.898, 2.32) and pack-years of cigarette use (OR per 10 pack-years=1.09, 95% CI=1.04, 1.14). A model including those four factors had a greater area under the receiver operating characteristics curve than did a model based on GERD frequency and duration alone (0.72 vs. 0.61, P<0.001), and it had a net reclassification improvement index of 19-25%.CONCLUSIONS:The prevalence of Barrett's esophagus was substantial in our population of older overweight men. A model based on GERD, age, abdominal obesity, and cigarette use more accurately classified the presence of Barrett's esophagus than did a model based on GERD alone. Following validation of the tool in another population, its use in clinical practice might improve the efficiency of screening for Barrett's esophagus.Am J Gastroenterol advance online publication, 15 January 2013; doi:10.1038/ajg.2012.446. |
| | |
Authors:
|
Joel H Rubenstein; Hal Morgenstern; Henry Appelman; James Scheiman; Philip Schoenfeld; Laurence F McMahon; Valbona Metko; Ellen Near; Joan Kellenberg; Tal Kalish; John M Inadomi |
Related Documents
:
|
23457645 - Spatial distribution of cerebral white matter lesions predicts progression to mild cogn... 23511155 - A simple clinical risk nomogram to predict mortality-associated geriatric complications... 23548225 - Long-term follow-up of severely symptomatic women with adenomyoma treated with combinat... 23216095 - Breast cancer screening program: experiences of canadian women and their unmet needs. 20663555 - Childhood sexual abuse and adult sexual health among indigenous kanak women and non-kan... 17497705 - Functional impairment associated with bulimic behaviors in a community sample of men an... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-15 |
Journal Detail:
|
Title: The American journal of gastroenterology Volume: - ISSN: 1572-0241 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1] Center for Clinical Management Research, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan, USA [2] Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, Michigan, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A Dual-Action, Low-Volume Bowel Cleanser Administered the Day Before Colonoscopy: Results From the S...
Next Document: Risk of Cancer in Patients With Autoimmune Pancreatitis.