Document Detail

Predicting which children are at risk for ependymoma relapse.
MedLine Citation:
PMID:  16575538     Owner:  NLM     Status:  MEDLINE    
Ependymomas account for 6-12% of all pediatric intracranial tumors. Despite complete resection and radiation, about 50% of patients relapse and have subsequent dismal prognoses. As no clinical findings reliably forecast tumor recurrence, we sought to determine if gene expression profiling could be used to distinguish patients at high risk for relapse at initial diagnosis, and thereby make them candidates for innovative treatments at an early stage. We extracted RNA from 13 ependymoma specimens: 7 from patients who experienced tumor recurrence, and 6 from patients who have not recurred. RNA was applied to Affymetrix HG-U133 plus 2.0 microarray chips, and microarrays were analyzed with GeneSpring 7.0 and Prediction Analysis of Microarrays (PAM) software. The 3-gene subset of PLEK (pleckstrin), NF-kappaB2 (nuclear factor kappa beta-2), and LOC374491 (TPTE and PTEN homologous inositol phosphatase pseudogene) was identified as the minimal subset capable of accurately distinguishing tumors according to recurrence. In summary, gene expression profiling may be valuable, perhaps in combination with clinical findings identified in some studies, for identifying children at high risk for ependymoma relapse.
Kristina Sowar; Jennifer Straessle; Andrew M Donson; Michael Handler; Nicholas K Foreman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-03-31
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  78     ISSN:  0167-594X     ISO Abbreviation:  J. Neurooncol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-23     Completed Date:  2006-08-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
University of Colorado at Denver and Health Sciences Center (UCDHSC) and Denver Children's Hospital, Denver, Colorado 80045, USA.
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MeSH Terms
Brain Neoplasms / classification,  genetics*,  pathology*
Child, Preschool
Ependymoma / classification,  genetics*,  pathology*
Gene Expression Profiling
Neoplasm Recurrence, Local / pathology*
Oligonucleotide Array Sequence Analysis
RNA, Messenger / analysis
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
Risk Factors
Grant Support
Reg. No./Substance:
0/RNA, Messenger

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