| Predicting type I diabetes. | |
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MedLine Citation:
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PMID: 2201499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Currently, there are three markers that are being studied with the potential to give a high positive predictive value for the development of type I diabetes (insulin-dependent diabetes caused by autoimmune beta-cell destruction) and that can be utilized to predict the disease in susceptible relatives: 1) high-titer cytoplasmic islet cell antibodies, 2) insulin autoantibodies detected with fluid-phase radiobinding assays, and 3) first-phase insulin release after intravenous glucose less than 1st percentile. With the combination of these assays, it seems to be possible to identify first-degree relatives with a high probability of developing type I diabetes within a limited time span (i.e., less than 10 yr). The ability to predict type I diabetes with selected assays will allow trials for prevention of diabetes and trials to assess whether prediction will decrease morbidity and mortality at onset of diabetes. |
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Authors:
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A G Ziegler; R D Herskowitz; R A Jackson; J S Soeldner; G S Eisenbarth |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Diabetes care Volume: 13 ISSN: 0149-5992 ISO Abbreviation: Diabetes Care Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1990-09-25 Completed Date: 1990-09-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 762-5 Citation Subset: IM |
Affiliation:
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Joslin Diabetes Center, Brigham and Women's Hospital, New England Deaconess Hospital, Boston, MA 02215. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autoantibodies
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analysis Biological Markers / analysis Child Diabetes Mellitus, Type 1 / diagnosis*, genetics, immunology Disease Susceptibility Genetic Markers Humans Insulin Antibodies / analysis Islets of Langerhans / immunology |
| Grant Support | |
ID/Acronym/Agency:
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R01-DK-32083-07/DK/NIDDK NIH HHS; R01-DK-33790-04/DK/NIDDK NIH HHS; R01-DK-39233-02/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Biological Markers; 0/Genetic Markers; 0/Insulin Antibodies; 0/islet cell antibody |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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