| Predicting tumor response after preoperative chemoradiation using clinical parameters in rectal cancer. | |
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MedLine Citation:
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PMID: 22219601 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate the clinical parameters and identify a better method of predicting pathological complete response (pCR). METHODS: We enrolled 249 patients from a database of 544 consecutive rectal cancer patients who underwent surgical resection after preoperative chemoradiation therapy (PCRT). A retrospective review of morphological characteristics was then performed to collect data regarding rectal examination findings. A scoring model to predict pCR was then created. To validate the ability of the scoring model to predict complete regression. RESULTS: Seventy patients (12.9%) achieved a pCR. A multivariate analysis found that pre-CRT movability (P = 0.024), post-CRT size (P = 0.018), post-CRT morphology (P = 0.023), and gross change (P = 0.009) were independent predictors of pCR. The accuracy of the scoring model was 76.8% for predicting pCR with the threshold set at 4.5. In the validation set, the accuracy was 86.7%. CONCLUSION: Gross changes and morphological findings are important predictors of pathological response. Accordingly, PCRT response is best predicted by a combination of clinical, laboratory and metabolic information. |
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Authors:
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Chan Ho Park; Hee Cheol Kim; Yong Beom Cho; Seong Hyeon Yun; Woo Yong Lee; Young Suk Park; Doo Ho Choi; Ho-Kyung Chun |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 17 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-01-05 Completed Date: 2012-03-02 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 5310-6 Citation Subset: IM |
Affiliation:
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Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-dong 50, Gangnam-gu, Seoul 135-710, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Area Under Curve Chemoradiotherapy / methods* Female Humans Male Middle Aged Multivariate Analysis Rectal Neoplasms / drug therapy*, pathology*, radiotherapy*, surgery Retrospective Studies Treatment Outcome Young Adult |
| Comments/Corrections | |
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