Document Detail

Predicting success of vagus nerve stimulation (VNS) from interictal EEG.
MedLine Citation:
PMID:  21514181     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Vagus nerve stimulation (VNS) has shown to be an effective treatment for drug resistant epilepsy in numerous patients, however, not in all. It is still not possible to predict which patients will profit from VNS. In this pilot study, we explore predictive interictal EEG features for seizure reduction after VNS.
METHODS: 19 Patients with medically refractory epilepsy and an implanted VNS system were included. Interictal EEG registrations, recorded before implantation, were retrospectively analysed. A quantative symmetry measure, the pair wise derived brain symmetry index (pdBSI), was tested to predict VNS outcome. Reduction in seizure frequency was used to define the responders.
RESULTS: 10 Patients did respond to VNS, of whom 7 patients had a seizure reduction of at least 50% in a follow-up period of 2 years. On average, we find higher pdBSI values for delta, theta, alpha and beta bands for non-responders than for responders. The average pdBSI of the theta and alpha bands could significantly discriminate between responders and non-responders.
CONCLUSION: In this study, quantifying EEG symmetry using the pdBSI shows promising results in predicting the reduction of seizure frequency after VNS treatment.
C C de Vos; L Melching; J van Schoonhoven; J J Ardesch; A W de Weerd; H C E van Lambalgen; M J A M van Putten
Publication Detail:
Type:  Journal Article     Date:  2011-04-21
Journal Detail:
Title:  Seizure     Volume:  20     ISSN:  1532-2688     ISO Abbreviation:  Seizure     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-07-29     Completed Date:  2011-12-12     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  541-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cerebral Cortex / physiopathology*
Epilepsy / physiopathology,  therapy*
Follow-Up Studies
Middle Aged
Predictive Value of Tests
Retrospective Studies
Treatment Outcome
Vagus Nerve Stimulation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Improvement in 2-year survival for ventricular assist device patients after implementation of an int...
Next Document:  Identification of Cardiac Dysfunction in Sepsis with B-Type Natriuretic Peptide.