| Predicting the solubility of sulfamethoxypyridazine in individual solvents. I: Calculating partial solubility parameters. | |
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MedLine Citation:
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PMID: 2778657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sulfamethoxypyridazine, a representative model of a drug molecule, is used to test the extended Hansen method for estimating partial solubility parameters of solid compounds. Solubilities are determined in polar and nonpolar solvents. The method provides reasonable partial parameters for the sulfonamide, and it may be useful in obtaining partial parameters for other drug molecules. A four-parameter extended Hansen approach involving proton donor and acceptor parameters is used in fitting the data to a theoretical model. A term, Wh, is introduced as an empirical measure of solute-solvent interactions due to hydrogen bonding. The use of the empirical term Wh allows the researcher to fit experimental solubilities and thus design regression models and equations which provide a reasonable prediction of solubilities of a polar drug in a number of very different solvents. A Flory-Huggins size correction term improves the prediction of sulfamethoxypyridazine solubilities in these irregular solutions. |
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Authors:
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P Bustamante; B Escalera; A Martin; E Sellés |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 78 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1989 Jul |
Date Detail:
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Created Date: 1989-10-17 Completed Date: 1989-10-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 567-73 Citation Subset: IM |
Affiliation:
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Departamento de Farmacia Galénica, Facultad de Farmacia, Universidad de Alcalá de Henares, Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chemistry, Physical Hydrogen Bonding Physicochemical Phenomena Solubility Solvents Sulfamethoxypyridazine / analysis* Thermodynamics |
| Chemical | |
Reg. No./Substance:
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0/Solvents; 80-35-3/Sulfamethoxypyridazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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