| Predicting the severity of relapsing-remitting MS: The contribution of cross-sectional and short-term follow-up MRI data. | |
| | |
MedLine Citation:
|
PMID: 21228028 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background and objective: Predicting the long-term clinical course of multiple sclerosis (MS) is difficult on clinical grounds. Recent studies have suggested magnetic resonance imaging (MRI) metrics to be helpful. We wanted to confirm this. Methods: Contactable individuals (N = 84) from an initial 99 patients with relapsing-remitting MS (RRMS) who had undergone careful baseline and 2-year follow-up examinations including MRI were reassessed after a mean of 10.8 ± 2.7 years. We investigated using multivariate linear regression analyses if clinical and MRI data obtained at the prior time-points and the rates of change in morphologic variables over a mean observational period of 2.5 years could have served to predict a patient's MS severity score (MSSS) 11 years later. Conversion to secondary progressive MS (SPMS) was a further outcome variable. Results: In univariate analyses, the 'black hole ratio' (BHR) at baseline (p = 0.017, beta = 0.148) and at first follow-up (p = 0.007, beta = -0.154) was the only MRI parameter showing a significant correlation with the MSSS. In a multiple regression model, the independent predictive value of imaging variables became statistically non-significant and the latest MSSS was predicted primarily by the baseline EDSS (r (2 )= 0.28; p < 0.001). The BHR at baseline explained 9.4% of variance of conversion to SPMS (p = 0.033). Over the observational period the MSSS remained stable in patients remaining RRMS, but increased in converters to SPMS from 4.0 to 6.4. Conclusions: We failed to confirm a clear independent contribution of cross-sectional and short-term follow-up MRI data for the prediction of the long-term clinical course of MS. The MSSS is not a stable indicator of disease severity but may increase in converters to SPMS. |
| | |
Authors:
|
C Enzinger; S Fuchs; A Pichler; M Wallner-Blazek; M Khalil; C Langkammer; S Ropele; F Fazekas |
Related Documents
:
|
9888408 - Direct detection of intratumoral 5-fluorouracil trapping using metabolic 19f mr imaging. 3170838 - Use of phosphorus-31 mr spectroscopy to monitor response to chemotherapy in non-hodgkin... 21512878 - Novel handheld pet probes provide intraoperative localization of pet-avid lymph nodes. 8748188 - Hydrogen magnetic resonance spectroscopy follow-up after radiation therapy of human bra... 16488208 - The value of magnetic resonance imaging in the diagnosis and management of extra-uterin... 11271548 - Alveolar soft part sarcoma: mr and angiographic findings. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-1-12 |
Journal Detail:
|
Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: - ISSN: 1477-0970 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-1-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Neurology, Medical University of Graz/ Division of Neuroradiology, Department of Radiology, Medical University of Graz, Graz, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A Swedish national post-marketing surveillance study of natalizumab treatment in multiple sclerosis.
Next Document: Safety and tolerability of cladribine tablets in multiple sclerosis: the CLARITY (CLAdRIbine Tablets...