Document Detail

Predicting the risk of preeclampsia and small for gestational age infants by uterine artery Doppler in low-risk women.
MedLine Citation:
PMID:  12942242     Owner:  NLM     Status:  MEDLINE    
The objective was to assess the value of uterine artery notching as a screening test for preeclampsia and fetal growth restriction in a low-risk population of healthy pregnant women. Color Doppler ultrasound was used to examine both uterine arteries in 322 healthy pregnant women at 24.9 +/- 1.9 (range 22-28) weeks of gestation. The criterion for abnormal results was a unilateral or bilateral presence of an early diastolic notch. The major end points were preeclampsia and small for gestational age (SGA) infants. Of the 322 women, 19 (5.9%) developed preeclampsia and six of them (1.9%) delivered SGA infants. An early diastolic notch was detected in 58 women (18%). The risk of developing preeclampsia and SGA infants in an abnormal Doppler study group was found to be greater than in that of a normal group (P<0.05). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for detecting preeclampsia were 36.8, 83.2, 12.1, and 95.5%, respectively; whereas detecting SGA infants were 67, 82.9, 6.9, and 99.2%, respectively. Women with an early diastolic notch have considerably a higher risk of developing preeclampsia and SGA infants. On the other hand, women with normal uterine artery waveforms are unlikely to develop preeclampsia and SGA infants. The test may be useful to minimize unnecessary interventions.
Vorapong Phupong; Thewin Dejthevaporn; Somchai Tanawattanacharoen; Saknan Manotaya; Yuen Tannirandorn; Dhiraphongs Charoenvidhya
Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2002-09-27
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  268     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-27     Completed Date:  2004-03-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  158-61     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Rama IV Road, Pathumwan, Bangkok 10330, Thailand.
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MeSH Terms
Arteries / physiology*
Fetal Growth Retardation / physiopathology,  ultrasonography*
Infant, Newborn
Infant, Small for Gestational Age
Pre-Eclampsia / physiopathology,  ultrasonography*
Predictive Value of Tests
Pregnancy Outcome
Pulsatile Flow
Regional Blood Flow
Sensitivity and Specificity
Ultrasonography, Doppler
Ultrasonography, Prenatal / standards*
Uterus / blood supply*

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