Document Detail

Predicting recurrence and metastasis of stage II/Dukes' B colorectal cancer without lymph node metastasis.
MedLine Citation:
PMID:  15492804     Owner:  NLM     Status:  MEDLINE    
This study was designed to compare the prediction of recurrence based on detection of occult neoplastic cells (ONCs) in lymph nodes or by using high-risk criteria for recurrence/metastasis in patients with Dukes' B colorectal cancer. Prediction of recurrence based on the detection of ONCs had a sensitivity of 59.1% (13/22), a false-positive rate of 7.8% (8/102), a specificity of 92.2% (94/102), and a negative predictive value (NPV) of 91.3% (94/103). Prediction of recurrence based on positivity for at least 2 of the 3 high-risk criteria had a sensitivity of 90.9% (20/22), a false-positive rate of 49.0% (50/102), a specificity of 51.0% (52/102), and an NPV of 96.3% (52/54). Among the 21 patients in whom ONCs were detected, prediction of recurrence based on the presence of all 3 high-risk criteria including ONCs had a sensitivity of 84.6% (11/13) and a positive predictive value (PPV) of 78.6% (11/14). These results suggest that colorectal cancer is unlikely to recur in patients without ONCs, while recurrence is likely in patients who fulfill 2 or more of the high-risk criteria. Accordingly, a combination of these parameters may be useful for the early prediction of recurrence/metastasis to assist in the choice of postoperative systemic chemotherapy.
Masaya Mukai; Shinkichi Sato; Takayuki Tajima; Hiromi Ninomiya; Tomomi Kimura; Nobukazu Komatsu; Hisao Nakasaki; Hiroyasu Makuuchi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncology reports     Volume:  12     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-19     Completed Date:  2004-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1127-30     Citation Subset:  IM    
Department of Surgery, Tokai University, Oiso Hospital, Oiso, Kanagawa 259-0198, Japan.
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MeSH Terms
Colorectal Neoplasms / diagnosis*,  secondary*
Lymph Nodes / metabolism
Lymphatic Metastasis
Neoplasm Recurrence, Local / diagnosis*
Neoplasm Staging
Risk Factors
Sensitivity and Specificity

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