| Predicting recurrence and metastasis of stage II/Dukes' B colorectal cancer without lymph node metastasis. | |
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MedLine Citation:
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PMID: 15492804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to compare the prediction of recurrence based on detection of occult neoplastic cells (ONCs) in lymph nodes or by using high-risk criteria for recurrence/metastasis in patients with Dukes' B colorectal cancer. Prediction of recurrence based on the detection of ONCs had a sensitivity of 59.1% (13/22), a false-positive rate of 7.8% (8/102), a specificity of 92.2% (94/102), and a negative predictive value (NPV) of 91.3% (94/103). Prediction of recurrence based on positivity for at least 2 of the 3 high-risk criteria had a sensitivity of 90.9% (20/22), a false-positive rate of 49.0% (50/102), a specificity of 51.0% (52/102), and an NPV of 96.3% (52/54). Among the 21 patients in whom ONCs were detected, prediction of recurrence based on the presence of all 3 high-risk criteria including ONCs had a sensitivity of 84.6% (11/13) and a positive predictive value (PPV) of 78.6% (11/14). These results suggest that colorectal cancer is unlikely to recur in patients without ONCs, while recurrence is likely in patients who fulfill 2 or more of the high-risk criteria. Accordingly, a combination of these parameters may be useful for the early prediction of recurrence/metastasis to assist in the choice of postoperative systemic chemotherapy. |
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Authors:
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Masaya Mukai; Shinkichi Sato; Takayuki Tajima; Hiromi Ninomiya; Tomomi Kimura; Nobukazu Komatsu; Hisao Nakasaki; Hiroyasu Makuuchi |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Oncology reports Volume: 12 ISSN: 1021-335X ISO Abbreviation: Oncol. Rep. Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-10-19 Completed Date: 2004-12-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9422756 Medline TA: Oncol Rep Country: Greece |
Other Details:
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Languages: eng Pagination: 1127-30 Citation Subset: IM |
Affiliation:
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Department of Surgery, Tokai University, Oiso Hospital, Oiso, Kanagawa 259-0198, Japan. onc-res@oiso.u-tokai.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Colorectal Neoplasms
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diagnosis*,
secondary* Humans Lymph Nodes / metabolism Lymphatic Metastasis Neoplasm Recurrence, Local / diagnosis* Neoplasm Staging Risk Factors Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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