| Predicting pulmonary hypoplasia with 2- or 3-dimensional ultrasonography in complicated pregnancies. | |
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MedLine Citation:
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PMID: 18166330 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to compare 3-dimensional (3D) lung volume measurements with 2-dimensional (2D) biometric parameters in predicting pulmonary hypoplasia in complicated pregnancies. STUDY DESIGN: In this prospective study, 1-4 scans of the fetal lungs were obtained in 33 pregnancies complicated by various disorders or complications with regard to pulmonary hypoplasia. The 3D lung volumes vs gestational age or estimated fetal weight, the thoracic circumference vs gestational age or femur length, the thoracic/abdominal circumference ratio, and the thoracic/heart area ratio were measured. RESULTS: Of the 33 infants, 16 (48.5%) were diagnosed with pulmonary hypoplasia on postmortem examination or the clinical and radiological presentation. Three dimensional lung volume measurements had a better diagnostic accuracy for predicting pulmonary hypoplasia (sensitivity, 94%; specificity, 82%; positive predictive value [PPV], 83%; negative predictive value [NPV], 93%), compared with the best 2D biometric measurement thoracic/heart area ratio (sensitivity, 94%; specificity, 47%; PPV, 63%; NPV, 89%). CONCLUSION: 3D lung volume measurements seem to be useful in predicting pulmonary hypoplasia prenatally. |
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Authors:
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Franca A Gerards; Jos W R Twisk; Willem P F Fetter; Liliane C D Wijnaendts; John M G van Vugt |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 198 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-01 Completed Date: 2008-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 140.e1-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands. fa.gerards@vumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Fetal Diseases / ultrasonography Fetal Organ Maturity / physiology* Gestational Age Humans Imaging, Three-Dimensional Infant, Newborn Lung / embryology*, ultrasonography Lung Volume Measurements Predictive Value of Tests Pregnancy Pregnancy Outcome Pregnancy, High-Risk* Prospective Studies Risk Factors Sensitivity and Specificity Severity of Illness Index Ultrasonography, Doppler / methods* Ultrasonography, Prenatal / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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