| Predicting and preventing the emergence of antiviral drug resistance in HSV-2. | |
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MedLine Citation:
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PMID: 9623975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genital herpes, caused by herpes simplex virus, is the most prevalent sexually transmitted disease worldwide. In many developing countries genital herpes is untreated, and in the United States only 10% of cases are treated. We present a mathematical model that we use as a health policy tool to predict the levels of antiviral drug resistance that would emerge, if treatment rates were increased, and to identify the key factors in determining the emergence of drug resistance. We use our results to suggest control measures for herpes epidemics that would prevent the emergence of substantial levels of antiviral drug resistance. |
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Authors:
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S M Blower; T C Porco; G Darby |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Nature medicine Volume: 4 ISSN: 1078-8956 ISO Abbreviation: Nat. Med. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-06-26 Completed Date: 1998-06-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9502015 Medline TA: Nat Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 673-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of California San Francisco, 94143, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antiviral Agents
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therapeutic use* Drug Resistance, Microbial* Epidemiologic Studies Herpes Genitalis / drug therapy*, prevention & control* Herpesvirus 2, Human / drug effects* Humans Models, Biological Predictive Value of Tests Sensitivity and Specificity Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01-09531//PHS HHS; R29DA08153/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents |
| Comments/Corrections | |
Comment In:
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Nat Med. 1998 Jun;4(6):664-5
[PMID:
9623969
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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