| Predicting preterm delivery: comparison of cervicovaginal interleukin (IL)-1beta, IL-6 and IL-8 with fetal fibronectin and cervical dilatation. | |
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MedLine Citation:
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PMID: 11301160 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the cervicovaginal cytokines IL-1beta, IL-6 and IL-8 with fetal fibronectin (fFN) and cervical dilatation in the prediction of preterm delivery. STUDY DESIGN: Cervicovaginal cytokine concentration and fFN status were measured in 104 women with symptoms of preterm labour and intact membranes between 24(0) and 33(6) weeks and related to delivery within 2 and 7 days. RESULTS: A group of 18% had cervical dilatation > or = 1cm and 18% were positive for fFN. Preterm delivery within 2 and 7 days occurred in 5 and 12%, respectively. Only IL-6 demonstrated any ability to predict delivery within 2 and 7 days (area under the ROC curve = 0.63 and 0.75, respectively). Using 35pg/ml (75th centile) as a cut-off, IL-6 had a sensitivity and specificity of 60 and 77% for predicting delivery within 2 days, and 62 and 80% for predicting delivery within 7 days. This is similar to the performance of cervical dilatation or fFN status. CONCLUSIONS: Measurement of cervicovaginal cytokines has limited ability to predict imminent delivery apart from cervicovaginal IL-6 concentrations, which, in this population, is equivalent to that of fFN status and cervical dilatation > or = 1cm. |
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Authors:
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M A Coleman; J A Keelan; L M McCowan; K M Townend; M D Mitchell |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 95 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-04-13 Completed Date: 2001-07-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 154-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, University of Auckland School of Medicine, Private Bag 92019, Auckland, New Zealand. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cervix Uteri / metabolism*, physiopathology* Female Fibronectins* Gestational Age Glycoproteins / analysis* Humans Interleukin-1 / analysis Interleukin-6 / analysis Interleukin-8 / analysis Interleukins / analysis* Logistic Models Obstetric Labor, Premature / diagnosis* Pregnancy Prospective Studies ROC Curve Vagina / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/FFN protein, human; 0/Fibronectins; 0/Glycoproteins; 0/Interleukin-1; 0/Interleukin-6; 0/Interleukin-8; 0/Interleukins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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