Document Detail


Predicting the potential gradient field in ventricular fibrillation from shocks delivered in paced rhythm.
MedLine Citation:
PMID:  7611485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A method of defibrillation threshold determination that utilizes low-strength shocks delivered in a benign rhythm would be desirable. Because the two-dimensional epicardial potential gradient (PG) is a shock parameter that is linked to defibrillation, we examined whether the epicardial PG measured for shocks delivered in paced rhythm could be used to predict the PG for defibrillation-strength shocks delivered in ventricular fibrillation (VF). In six open-chest pentobarbital-anesthetized pigs with left ventricular apex and right atrial internal defibrillation patches, we measured the epicardial PG field for shocks delivered in paced rhythm and during VF. We determined that there was a linear relationship between epicardial PG and shock strength for shocks delivered in paced rhythm. However, prediction of the PG measured for shocks in VF from those measured in paced rhythm resulted in a statistically significant overestimation of the PG in VF. We conclude that, for equivalent strength shocks, the epicardial PG field is weaker for shocks delivered in VF. This change in the potential gradient field can have an effect on defibrillation threshold estimates that are based on shocks delivered in paced rhythm.
Authors:
S F Idriss; S B Melnick; P D Wolf; W M Smith; R E Ideker
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  268     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-08-14     Completed Date:  1995-08-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H2336-44     Citation Subset:  IM    
Affiliation:
Department of Medicine, Duke University Medical Center, Durham 27710, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Electric Countershock*
Heart / physiology*,  physiopathology*
Models, Cardiovascular
Models, Theoretical
Swine
Time Factors
Ventricular Fibrillation / physiopathology*
Grant Support
ID/Acronym/Agency:
HL-28429/HL/NHLBI NIH HHS; HL-42760/HL/NHLBI NIH HHS; HL-44066/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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