| Predicting post-transplant diabetes mellitus by regulatory T cell phenotype: implications for metabolic intervention to modulate alloreactivity. | |
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MedLine Citation:
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PMID: 22262764 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Chronic inflammation and decreased frequency of regulatory T cells (Tregs) in visceral adipose tissue contribute to the propagation of insulin resistance to diabetes mellitus. We tested the hypothesis that new-onset post-transplant diabetes mellitus (PTDM) is associated with measurable changes in Treg subsets following allogeneic hematopoietic stem cell transplantation (HCT). PTDM before day+100 and Treg phenotype at engraftment were determined in 36 HCT recipients without preceding history of diabetes mellitus. Among patients with new onset PTDM (N= 24), the frequency of circulating CLA(+) (skin-homing) Tregs was decreased (1.53% vs. 3.99%; P=0.002) and the percentage of α(4)β(7)(+) (gut-homing) Tregs was increased (17.9% vs. 10.7%; P=0.048). In multivariate analysis patients with PTDM continued to demonstrate elevated ratios of α(4)β(7)(+) Tregs to CLA(+) Tregs (odds ratio, 18.1; P=0.020). PTDM is associated with altered immune regulation post-HCT and could represent a target to modulate alloreactivity. |
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Authors:
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Brian G Engelhardt; Shubhada M Jagasia; James E Crowe; Michelle L Griffith; Bipin N Savani; Adetola A Kassim; Pengcheng Lu; Jörn-Hendrik Weitkamp; Daniel J Moore; Sandra M Yoder; Michael T Rock; Madan Jagasia |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-19 |
Journal Detail:
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Title: Blood Volume: - ISSN: 1528-0020 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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