Document Detail


Predicting perinatal outcome in isolated congenital diaphragmatic hernia using fetal pulmonary artery diameters.
MedLine Citation:
PMID:  18405704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The aim of the study was to evaluate the potential of fetal pulmonary artery (PA) diameters to predict perinatal death and pulmonary arterial hypertension (PAH) in congenital diaphragmatic hernia (CDH). STUDY DESIGN: In this prospective observational study, observed PA (main, right, and left) diameters were measured at the level of the 3 vessels in 21 fetuses with isolated CDH and in 85 controls at 22 to 36 weeks. The observed/expected (o/e) diameters of the main, contralateral, and ipsilateral PAs were calculated by comparing these measurements with reference values obtained in our previous study and correlated with perinatal death and postnatal PAH. RESULTS: The o/e PA diameters were significantly reduced in fetuses with CDH compared to controls (P < .001) and in fetuses with CDH who died (P < .050). However, there was no significant association between PA diameters and PAH (P >or= .050). CONCLUSIONS: The PA diameters might be useful to predict perinatal death in isolated CDH but not postnatal PAH, suggesting that PA diameters are probably related to the severity of pulmonary hypoplasia.
Authors:
Rodrigo Ruano; Marie-Cécile Aubry; Bruno Barthe; Delphine Mitanchez; Yves Dumez; Alexandra Benachi
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  43     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-14     Completed Date:  2008-06-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  606-11     Citation Subset:  IM    
Affiliation:
Université Paris-Descartes, Faculté de Médecine, AP-HP, Maternité, Hôpital Necker-Enfants Malades, 75743 cedex 15, Paris, France. rodrigoruano@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Hernia, Diaphragmatic / complications,  congenital*,  diagnosis*
Humans
Hypertension, Pulmonary / diagnosis*,  etiology
Prospective Studies
Pulmonary Artery / embryology*,  ultrasonography*
Ultrasonography, Prenatal
Weights and Measures

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