Document Detail

Predicting perinatal mortality in preterm intrauterine growth restriction.
MedLine Citation:
PMID:  19670130     Owner:  NLM     Status:  MEDLINE    
We evaluated if maternal demographic and ultrasound parameters predict perinatal mortality in preterm intrauterine growth restriction (IUGR). Retrospective cohort study of preterm IUGR (delivery gestational age <35 weeks and birth weight <10th percentile for gestation). We excluded twins and fetuses with aneuploidy, intrauterine infection, or major congenital malformations. Information collected included maternal demographic and medical information, estimated fetal weight, oligohydramnios (amniotic fluid index <5), abnormal umbilical artery Dopplers (absent or reverse end-diastolic flow), and abnormal biophysical score (score <6). Our outcome was perinatal mortality, which was defined as in utero death or neonatal death within the first 28 days of life. Statistical analysis included bivariate and multivariable techniques as well as receiver operator characteristic analysis. Two hundred thirty singleton pregnancies with preterm IUGR meeting the inclusion criteria were identified. Variables associated with perinatal mortality included oligohydramnios and abnormal umbilical artery Dopplers. These two variables had modest predictive value for perinatal mortality. In cases of preterm IUGR, only the presence of abnormal umbilical artery Dopplers or oligohydramnios predicts perinatal mortality.
Christina M Scifres; David Stamilio; George A Macones; Anthony O Odibo
Publication Detail:
Type:  Journal Article     Date:  2009-05-20
Journal Detail:
Title:  American journal of perinatology     Volume:  26     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-20     Completed Date:  2010-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  723-8     Citation Subset:  IM    
Copyright Information:
(c) Thieme Medical Publishers.
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
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MeSH Terms
Cohort Studies
Fetal Growth Retardation / epidemiology,  mortality*,  ultrasonography*
Multivariate Analysis
Obstetric Labor, Premature / mortality*,  ultrasonography
Oligohydramnios / ultrasonography*
Predictive Value of Tests
Pregnancy Outcome / epidemiology
Retrospective Studies
Risk Assessment / methods
Ultrasonography, Prenatal / methods
Umbilical Arteries / ultrasonography*

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