| Predicting nucleosome positions in yeast: using the absolute frequency. | |
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MedLine Citation:
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PMID: 22292961 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Nucleosome is the basic structure of chromatin in eukaryotic cells, and they form the chromatin fiber interconnected by sections of linker DNA. Nucleosome positioning is of great significance for gene transcription regulation. In this paper, we consider the difference of absolute frequency of nucleotides between the nucleosome forming and nucleosome inhibiting sequences. Based on the 2-mer absolute frequency of nucleotides in genome, a new model is constructed to distinguish nucleosome DNA and linker DNA. When used to predict DNA potential for forming nucleosomes in S. cerevisiae, the model achieved a high accuracy of 96.05%. Thus, the model is very useful for predicting nucleosome positioning. |
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Authors:
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Z Zhang; Y Zhang; I Gutman |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biomolecular structure & dynamics Volume: 29 ISSN: 1538-0254 ISO Abbreviation: J. Biomol. Struct. Dyn. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8404176 Medline TA: J Biomol Struct Dyn Country: United States |
Other Details:
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Languages: eng Pagination: 1081-8 Citation Subset: IM |
Affiliation:
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School of Mathematics and Statistics, Shandong University at Weihai, Weihai 264209, China. zhangys@sdu.edu.cn. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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