Document Detail

Predicting neuroleptic response from a combination of multilevel variables in acute schizophrenic patients.
MedLine Citation:
PMID:  1981296     Owner:  NLM     Status:  MEDLINE    
A predetermined set of 22 sociodemographic, psychosocial, clinical, neurocognitive and biochemical potential predictor variables was tested in 98 schizophrenic patients admitted for relapse. The patients were treated with neuroleptics, mostly with haloperidol, for 28 d. Ten of the 22 variables correlated significantly with the neuroleptic response. Using stepwise multiple regression analyses, an optimal combination of 5 predictors was found to be in hierarchical order: disturbances of premorbid adjustment, intensity of positive symptoms at admission, family history of schizophrenia, working ability during the year before admission and serum dopamine-beta-hydroxylase. The 5 best predictors explained 29% of outcome variance, and all 22 variables together explained 35%. Such neurological characteristics as neurological soft signs, handedness, abnormal voluntary movements, spontaneous blink rate and cognitive impairment did not predict the treatment response. Several psychopathological, psychosocial and clinical predictors known from the literature could also be confirmed by cross-validation.
G Bartkó; E Frecska; S Horváth; G Zádor; M Arató
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta psychiatrica Scandinavica     Volume:  82     ISSN:  0001-690X     ISO Abbreviation:  Acta Psychiatr Scand     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-04-04     Completed Date:  1991-04-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370364     Medline TA:  Acta Psychiatr Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  408-12     Citation Subset:  IM    
National Institute for Nervous and Mental Diseases, Budapest, Hungary.
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MeSH Terms
Activities of Daily Living / psychology
Acute Disease
Antipsychotic Agents / adverse effects,  therapeutic use*
Dopamine beta-Hydroxylase / blood
Dose-Response Relationship, Drug
Dyskinesia, Drug-Induced / diagnosis
Haloperidol / adverse effects,  therapeutic use
Life Change Events
Middle Aged
Neurologic Examination / statistics & numerical data
Psychiatric Status Rating Scales* / statistics & numerical data
Schizophrenia / drug therapy*
Schizophrenic Psychology*
Social Adjustment
Reg. No./Substance:
0/Antipsychotic Agents; 52-86-8/Haloperidol; EC beta-Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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