| Predicting neuroleptic response from a combination of multilevel variables in acute schizophrenic patients. | |
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MedLine Citation:
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PMID: 1981296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A predetermined set of 22 sociodemographic, psychosocial, clinical, neurocognitive and biochemical potential predictor variables was tested in 98 schizophrenic patients admitted for relapse. The patients were treated with neuroleptics, mostly with haloperidol, for 28 d. Ten of the 22 variables correlated significantly with the neuroleptic response. Using stepwise multiple regression analyses, an optimal combination of 5 predictors was found to be in hierarchical order: disturbances of premorbid adjustment, intensity of positive symptoms at admission, family history of schizophrenia, working ability during the year before admission and serum dopamine-beta-hydroxylase. The 5 best predictors explained 29% of outcome variance, and all 22 variables together explained 35%. Such neurological characteristics as neurological soft signs, handedness, abnormal voluntary movements, spontaneous blink rate and cognitive impairment did not predict the treatment response. Several psychopathological, psychosocial and clinical predictors known from the literature could also be confirmed by cross-validation. |
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Authors:
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G Bartkó; E Frecska; S Horváth; G Zádor; M Arató |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta psychiatrica Scandinavica Volume: 82 ISSN: 0001-690X ISO Abbreviation: Acta Psychiatr Scand Publication Date: 1990 Dec |
Date Detail:
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Created Date: 1991-04-04 Completed Date: 1991-04-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370364 Medline TA: Acta Psychiatr Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 408-12 Citation Subset: IM |
Affiliation:
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National Institute for Nervous and Mental Diseases, Budapest, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living
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psychology Acute Disease Adult Antipsychotic Agents / adverse effects, therapeutic use* Dopamine beta-Hydroxylase / blood Dose-Response Relationship, Drug Dyskinesia, Drug-Induced / diagnosis Female Haloperidol / adverse effects, therapeutic use Humans Life Change Events Male Middle Aged Neurologic Examination / statistics & numerical data Prognosis Psychiatric Status Rating Scales* / statistics & numerical data Psychometrics Schizophrenia / drug therapy* Schizophrenic Psychology* Social Adjustment |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 52-86-8/Haloperidol; EC 1.14.17.1/Dopamine beta-Hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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