Document Detail

Predicting mortality in infants with persistent pulmonary hypertension of the newborn with the Score for Neonatal Acute Physiology-Version II (SNAP-II) in Thai neonates.
MedLine Citation:
PMID:  21488808     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the ability of the Score for Neonatal Acute Physiology-Version II (SNAP-II) to predict mortality in infants with persistent pulmonary hypertension of the newborn (PPHN).
METHODS: A prospective cohort study of 41 infants with PPHN admitted to our neonatal intensive care unit between June 2008 and March 2010, who underwent a SNAP-II test within 12 h of admission.
RESULTS: Of the 41 infants, 14 died (34.1%) and 27 survived (65.9%). The SNAP-II scores were significantly higher in infants who died (50.1 ± 18.5 vs. 35.7 ± 16.8, P=0.02). Each point increase in the SNAP score increased the odds of mortality by 1.04 [95% confidence interval (CI) 1.01-1.07, P<0.01]. Infants who had a SNAP-II score of ≥ 43 had the greatest mortality risk with an odds ratio (OR) of 10.00 (95% CI 1.03-97.50). The SNAP-II model showed moderate discrimination in predicting mortality with a result of 0.72 (95% CI 0.56-0.88) under the receiver operating characteristic curve. The lowest blood pressure, lowest PaO(2)/FIO(2) ratio, and urine output within the first 12 h of admission were also independently found to be good predictors of an increased risk for death.
CONCLUSION: The SNAP-II scoring system significantly predicted mortality. PPHN infants with a SNAP-II score of ≥ 43 had the greatest mortality risk.
Narongsak Nakwan; Narongwit Nakwan; Jeerawan Wannaro
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Publication Detail:
Type:  Journal Article     Date:  2011-04-14
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  39     ISSN:  1619-3997     ISO Abbreviation:  J Perinat Med     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-10     Completed Date:  2011-08-25     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  311-5     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Cohort Studies
Infant, Newborn
Intensive Care, Neonatal
Odds Ratio
Oxygen / blood
Persistent Fetal Circulation Syndrome / mortality*
Prospective Studies
ROC Curve
Severity of Illness Index*
Thailand / epidemiology
Reg. No./Substance:

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